{"metadata":{"accession":"A0A665U8Z6","id":"A0A665U8Z6_ECHNA","source_organism":{"taxId":"173247","scientificName":"Echeneis naucrates","fullName":"Echeneis naucrates (Live sharksucker)"},"name":"NADPH oxidase 4","description":["NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release"],"length":527,"sequence":"MAVSLRSWVANEGGKHLVLMLWVGTNIWLFLKTFLLYSSGQQYHYLYKMLGLGLCISRASASVLNLNCSLVLLPMCRSLLTFVRGTDTVSSRKTRRLLDKSKTFHVACGVTICIFSVVHVSAHLVNVLNFSVSYSDDFPALNLALPGVTGVLLTLILFLMFMSSSYSNIRLIHVFTTSGALKYQTNIDAHPPGCLRANQSSTGSQGKELDRGEDEEQRCREEAHFQPHYPQTWLWVSGPLCLYCAERFYRYVRSSDPVTIVTVIKHPCDVFELRMLKKNFRARPGQYILLNCPNVSSFENHPFTLTTCPTENKETFGIHLRVVGDWTGRFTEMLLPQPRIGLDVLPMLQQRRYPKLYVDGPFGSPSEEVFNYDVSLCVAGGIGVTPFACVLHALLDGWTGFRLQRLYFVWVCRELQSFYWFAELLCALHHKLWQENRPDYFNLRLYLSRADGLQSMPEEKYRPLASRLLVGRPRWKLLFDEIGKTNKDKRVGVFCCGPKGISRTLHRLCNSGRSSGATFEFNKESFS","proteome":"UP000472264","gene":"nox4","go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"496ce31aafc2f777618f119f81f7277d9a382e44","counters":{"domain_architectures":22735,"entries":17,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"profile":1,"cathgene3d":2,"ssf":2,"cdd":1,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":22735}}}