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{
    "metadata": {
        "accession": "A0A4Z1CY64",
        "id": "A0A4Z1CY64_STRGP",
        "source_organism": {
            "taxId": "29306",
            "scientificName": "Streptomyces griseoluteus",
            "fullName": "Streptomyces griseoluteus"
        },
        "name": "Probable bifunctional transcriptional activator/DNA repair enzyme AlkA",
        "description": [
            "Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions",
            "The methylation of Alka by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene and other alkylation resistance genes"
        ],
        "length": 499,
        "sequence": "MRNATSSSRTPSLDREHCVHAVQSKDARFDGWFFTAVLTTRIYCRPSCPAVPPKAENMTFYPSAAACQRAGFRACKRCRPDATPGSPEWNHRADLVARAMRLIADGVVDREGVPGLAARLGYSARQIERQLFAELGAGPLSLARAQRAQTARLLIETTALPMAEVAFAAGFSSIRTFNDTVREVFALAPSDLRARAPRARSAGTAGTLTLRLPFRAPLNPGNLFGHLAATAVPGVEEWRDGAYRRTLRLPYGHGVVALTPGATHVGCRIGLSDLRDLTVAISRCRRLLDLDADPVAVDERLRGDPLLAPLVDAEPGRRVPRTVDEAEFAVRAVLGQQVSTAAARTHAARLVTAHGKPLDDPEGGLTHLFPDPDALAAVDPEALAMPRSRRATLTTLVGALADGTLKLGVEADRAEARARLLELPGFGPWTADVIAMRALGDPDAFLPTDLGVRRAARSLGLPATPAALTARAEAWRPWRAYAVQYLWATDSHPINFLPA",
        "proteome": "UP000298513",
        "gene": "E5082_31325",
        "go_terms": [
            {
                "identifier": "GO:0003700",
                "name": "DNA-binding transcription factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0043565",
                "name": "sequence-specific DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0003824",
                "name": "catalytic activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006281",
                "name": "DNA repair",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0006284",
                "name": "base-excision repair",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0008168",
                "name": "methyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0008270",
                "name": "zinc ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "f45011c20eb1ca31e2228d9947d58289283e872f",
        "counters": {
            "domain_architectures": 2015,
            "entries": 31,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 5,
                "ssf": 4,
                "profile": 1,
                "smart": 3,
                "pfam": 4,
                "cdd": 1,
                "panther": 1,
                "prosite": 1,
                "interpro": 11
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2015
        }
    }
}