{"metadata":{"accession":"A0A4Z1CY64","id":"A0A4Z1CY64_STRGP","source_organism":{"taxId":"29306","scientificName":"Streptomyces griseoluteus","fullName":"Streptomyces griseoluteus"},"name":"Probable bifunctional transcriptional activator/DNA repair enzyme AlkA","description":["Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions","The methylation of Alka by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene and other alkylation resistance genes"],"length":499,"sequence":"MRNATSSSRTPSLDREHCVHAVQSKDARFDGWFFTAVLTTRIYCRPSCPAVPPKAENMTFYPSAAACQRAGFRACKRCRPDATPGSPEWNHRADLVARAMRLIADGVVDREGVPGLAARLGYSARQIERQLFAELGAGPLSLARAQRAQTARLLIETTALPMAEVAFAAGFSSIRTFNDTVREVFALAPSDLRARAPRARSAGTAGTLTLRLPFRAPLNPGNLFGHLAATAVPGVEEWRDGAYRRTLRLPYGHGVVALTPGATHVGCRIGLSDLRDLTVAISRCRRLLDLDADPVAVDERLRGDPLLAPLVDAEPGRRVPRTVDEAEFAVRAVLGQQVSTAAARTHAARLVTAHGKPLDDPEGGLTHLFPDPDALAAVDPEALAMPRSRRATLTTLVGALADGTLKLGVEADRAEARARLLELPGFGPWTADVIAMRALGDPDAFLPTDLGVRRAARSLGLPATPAALTARAEAWRPWRAYAVQYLWATDSHPINFLPA","proteome":"UP000298513","gene":"E5082_31325","go_terms":[{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f45011c20eb1ca31e2228d9947d58289283e872f","counters":{"domain_architectures":2015,"entries":31,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"ssf":4,"profile":1,"smart":3,"pfam":4,"cdd":1,"panther":1,"prosite":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":2015}}}