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{
    "metadata": {
        "accession": "A0A4W2EH65",
        "id": "A0A4W2EH65_BOBOX",
        "source_organism": {
            "taxId": "30522",
            "scientificName": "Bos indicus x Bos taurus",
            "fullName": "Bos indicus x Bos taurus (Hybrid cattle)"
        },
        "name": "Interferon regulatory factor 8",
        "description": [
            "Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. Positively regulates macroautophagy in dendritic cells. Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1"
        ],
        "length": 426,
        "sequence": "MCDRNGGRRLRQWLIEQIDSTMYPGLIWENDEKTMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVAAPGCVSEAVEMECGRSEIDELIKEPPGDDYMGMVKRSPSPPEACRSQLLPDWWVQQPSAGLPLVPGYSAYDAHHSAFSQMVISFYYGGKLVGQTTTTCPEGCRLSLGQPGLLGGKLYGPEGLELVRFPPADTIPSERQRQVTRKLFGHLERGILLHSSRQGVLVKRLCQGRVFYSGNAAPARDRPNKLERDEVVRVFDTSQFFRELQQFYNSQSRLPDSRVVLCFGEEFPDTTPLRSKLILVQVEQLYVRQLVEEAGKGCGPGSLMQAPEEPPPDQVFRMFPEICASHQRPFFRENQQITV",
        "proteome": "UP000314981",
        "gene": "IRF8",
        "go_terms": [
            {
                "identifier": "GO:0000976",
                "name": "transcription cis-regulatory region binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003700",
                "name": "DNA-binding transcription factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "621619633400ed25eaadf7725f5360e2921ad3ae",
        "counters": {
            "domain_architectures": 7057,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "smart": 2,
                "ssf": 2,
                "cdd": 1,
                "profile": 1,
                "pfam": 2,
                "cathgene3d": 2,
                "panther": 1,
                "prints": 1,
                "prosite": 1,
                "interpro": 7
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 7057
        }
    }
}