{"metadata":{"accession":"A0A4W2EH65","id":"A0A4W2EH65_BOBOX","source_organism":{"taxId":"30522","scientificName":"Bos indicus x Bos taurus","fullName":"Bos indicus x Bos taurus (Hybrid cattle)"},"name":"Interferon regulatory factor 8","description":["Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. Positively regulates macroautophagy in dendritic cells. Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1"],"length":426,"sequence":"MCDRNGGRRLRQWLIEQIDSTMYPGLIWENDEKTMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVAAPGCVSEAVEMECGRSEIDELIKEPPGDDYMGMVKRSPSPPEACRSQLLPDWWVQQPSAGLPLVPGYSAYDAHHSAFSQMVISFYYGGKLVGQTTTTCPEGCRLSLGQPGLLGGKLYGPEGLELVRFPPADTIPSERQRQVTRKLFGHLERGILLHSSRQGVLVKRLCQGRVFYSGNAAPARDRPNKLERDEVVRVFDTSQFFRELQQFYNSQSRLPDSRVVLCFGEEFPDTTPLRSKLILVQVEQLYVRQLVEEAGKGCGPGSLMQAPEEPPPDQVFRMFPEICASHQRPFFRENQQITV","proteome":"UP000314981","gene":"IRF8","go_terms":[{"identifier":"GO:0000976","name":"transcription cis-regulatory region binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"621619633400ed25eaadf7725f5360e2921ad3ae","counters":{"domain_architectures":7057,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"smart":2,"ssf":2,"cdd":1,"profile":1,"pfam":2,"cathgene3d":2,"panther":1,"prints":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":7057}}}