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{
    "metadata": {
        "accession": "A0A4U1EID1",
        "id": "A0A4U1EID1_MONMO",
        "source_organism": {
            "taxId": "40151",
            "scientificName": "Monodon monoceros",
            "fullName": "Monodon monoceros (Narwhal)"
        },
        "name": "Fanconi-associated nuclease",
        "description": [
            "Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps",
            "Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions"
        ],
        "length": 1011,
        "sequence": "KSSKKRPRRSLSSSKTKKNESNSIIAFFNNVPPVKLACPICSKMVPRYDLNRHLDEMCANNGDITPADPGHVDLSSNVSTVDLTNIALEDVTPEKSSPSKINLTPGQSDAAKMGIKQQTSPYFKSNDDAVCRNQDGLRHHNVKVIPLGSLSSKLSRRYIKAKRSIDKNEGFANQSPQSFSSTGVRSLVDQCSEMEGQDQLLENSSQKENMFACNSLEEPSTPEHIVGGSTIMEAEGLTAAQELFSDNAPVLPSPDLTLGHKLKSASEDHLAKQESIKGTDDKGVENCEAGGCEEVKMTFVSQAPTQSSHWEAKSHNSTHDASIWSDSQALPPEGDSGSKNESTDRIPLEQGSSCDVSCVTSPAPPDHPYYLRSFLMVLKAVFENEEDRMLFDEHEKGIITKFHQLSASGQKLYVRLFQRKFGWIKMNKLEYEEISADLTPVVRELTHAGFLQTESELQELSEVLELLSAPELKALAKTFHLVNPSGQKQQLVNAFLKLAKQPSVCTWRKNQPGIGAVILKRAKDWAGQSLRVCRDPRAVFSRVLLLFSLTHEVEEEEAACGGQGQLSTVLLVNLGRMEFPRYTVSRKTQIFQDREDLIRYAAAAHMLNDISTAMASGAWEEARELARCAKQDWDGLKGHPSLRYHEKLPLFLRCFTVGWVYTRILSRTVEILQRLHIYEEAVKELENLLSQKVYCPDSRGRWWDRLALNLHQHLKRLEPAIKCITAGLADPDVRTGHRLSLYQRAVRLRASPSCQKYAHLFRQLPEVTVDDVKHVTVTGRLCPQSGPGKSVFVLEAGGTAPATVLCSVEELALAHYRRCGFDQGIHGEGSTFSTLYGLLLWDVIFMDGIPDAFRNAYQAAPLDLCTDSFFASRAPAIEARLRQIHGAPAESLRAWVAAAWQAQEGRVASLVSWDRFASLQQAQDLVSCLGGPILSGVCRRLATDFRHCRGGLPDLVVWSSRSHHVKLVEVKGPSDRLSQKQMIWLDELHRLGADVEVCHVAAVGAKSRGPN",
        "proteome": null,
        "gene": "EI555_006925",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006281",
                "name": "DNA repair",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016788",
                "name": "hydrolase activity, acting on ester bonds",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003676",
                "name": "nucleic acid binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004518",
                "name": "nuclease activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0036297",
                "name": "interstrand cross-link repair",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": true,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "86e31d071b1ea7670cd9baa03608a75e2de1bec4",
        "counters": {
            "domain_architectures": 921,
            "entries": 19,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "smart": 2,
                "cathgene3d": 2,
                "profile": 1,
                "cdd": 1,
                "pfam": 4,
                "panther": 1,
                "interpro": 8
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 921
        }
    }
}