{"metadata":{"accession":"A0A4U1EID1","id":"A0A4U1EID1_MONMO","source_organism":{"taxId":"40151","scientificName":"Monodon monoceros","fullName":"Monodon monoceros (Narwhal)"},"name":"Fanconi-associated nuclease","description":["Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps","Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions"],"length":1011,"sequence":"KSSKKRPRRSLSSSKTKKNESNSIIAFFNNVPPVKLACPICSKMVPRYDLNRHLDEMCANNGDITPADPGHVDLSSNVSTVDLTNIALEDVTPEKSSPSKINLTPGQSDAAKMGIKQQTSPYFKSNDDAVCRNQDGLRHHNVKVIPLGSLSSKLSRRYIKAKRSIDKNEGFANQSPQSFSSTGVRSLVDQCSEMEGQDQLLENSSQKENMFACNSLEEPSTPEHIVGGSTIMEAEGLTAAQELFSDNAPVLPSPDLTLGHKLKSASEDHLAKQESIKGTDDKGVENCEAGGCEEVKMTFVSQAPTQSSHWEAKSHNSTHDASIWSDSQALPPEGDSGSKNESTDRIPLEQGSSCDVSCVTSPAPPDHPYYLRSFLMVLKAVFENEEDRMLFDEHEKGIITKFHQLSASGQKLYVRLFQRKFGWIKMNKLEYEEISADLTPVVRELTHAGFLQTESELQELSEVLELLSAPELKALAKTFHLVNPSGQKQQLVNAFLKLAKQPSVCTWRKNQPGIGAVILKRAKDWAGQSLRVCRDPRAVFSRVLLLFSLTHEVEEEEAACGGQGQLSTVLLVNLGRMEFPRYTVSRKTQIFQDREDLIRYAAAAHMLNDISTAMASGAWEEARELARCAKQDWDGLKGHPSLRYHEKLPLFLRCFTVGWVYTRILSRTVEILQRLHIYEEAVKELENLLSQKVYCPDSRGRWWDRLALNLHQHLKRLEPAIKCITAGLADPDVRTGHRLSLYQRAVRLRASPSCQKYAHLFRQLPEVTVDDVKHVTVTGRLCPQSGPGKSVFVLEAGGTAPATVLCSVEELALAHYRRCGFDQGIHGEGSTFSTLYGLLLWDVIFMDGIPDAFRNAYQAAPLDLCTDSFFASRAPAIEARLRQIHGAPAESLRAWVAAAWQAQEGRVASLVSWDRFASLQQAQDLVSCLGGPILSGVCRRLATDFRHCRGGLPDLVVWSSRSHHVKLVEVKGPSDRLSQKQMIWLDELHRLGADVEVCHVAAVGAKSRGPN","proteome":null,"gene":"EI555_006925","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016788","name":"hydrolase activity, acting on ester bonds","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004518","name":"nuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0036297","name":"interstrand cross-link repair","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"86e31d071b1ea7670cd9baa03608a75e2de1bec4","counters":{"domain_architectures":921,"entries":19,"isoforms":0,"proteomes":0,"sets":5,"structures":0,"taxa":1,"dbEntries":{"smart":2,"cathgene3d":2,"profile":1,"cdd":1,"pfam":4,"panther":1,"interpro":8},"proteome":0,"taxonomy":1,"similar_proteins":921}}}