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{
    "metadata": {
        "accession": "A0A455AD42",
        "id": "A0A455AD42_PHYMC",
        "source_organism": {
            "taxId": "9755",
            "scientificName": "Physeter macrocephalus",
            "fullName": "Physeter macrocephalus (Sperm whale)"
        },
        "name": "Exostosin-2",
        "description": [
            "Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling"
        ],
        "length": 1103,
        "sequence": "MFTLPQKDSGTPTTCPGSVSTQGLHSNHGDGLERECSRKPDQKPLKLYGVGDPTAMFSSDSPYLSSRGSVIKWFWDSAEEGYRTYHMDEYDEEKNPSGIINLGTSENKLCFDLLSRRLSQSDMLRVELSLLQYPDWRGHLFLREEVARFLSFYCRSPTPLKPENVVVLNGCASLFSALATVLCEVGEAFLIPAPYYGAITQHVYLYGNVRLVCVYLDSEVTGLETRPFQLTVEKLEMALEGANSEGVKVKGLILINPQNPLGDVYSPGELQEYLKFAKRHELHVMVDEVYMLSVFEESVEYHSVLSLERLPDPQRTHVMWATSKDFGMSGLRFGTLYTENQDVATAVSSLCRYHGLSGLLQYQMAQLLRDRDWINQVYLPENRARLKAAHVYVSGELRALGIPFVSRGAGFFIWVDLRKECEEEALWVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGVFQFWPHSIESSSDWSVQKRSIRDVPVVRLPADSPVPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYSLKKYVDDAGVPVSSTISQEYNELLTAVSDSDYYTEDITRACLFIPSIDLLNQNALRVKETAQALAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVELPEKGPGPRRYFLLSSQMALHPEYREELAALQARHGEAALVLDKCTNLSEGIPAARKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLRAGCVPVIIADSYILPFSEVLDWKRASVAVPEEKMSDVYSILQSIPQRQIEEMQRQKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL",
        "proteome": "UP000248484",
        "gene": "LOC102979294",
        "go_terms": [
            {
                "identifier": "GO:0030170",
                "name": "pyridoxal phosphate binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0009058",
                "name": "biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016757",
                "name": "glycosyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0009101",
                "name": "glycoprotein biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "4a539015c239d48852cf3ec80341430434cf47bf",
        "counters": {
            "domain_architectures": 23,
            "entries": 19,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 2,
                "cathgene3d": 3,
                "cdd": 1,
                "pfam": 3,
                "panther": 1,
                "prints": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 23
        }
    }
}