{"metadata":{"accession":"A0A455AD42","id":"A0A455AD42_PHYMC","source_organism":{"taxId":"9755","scientificName":"Physeter macrocephalus","fullName":"Physeter macrocephalus (Sperm whale)"},"name":"Exostosin-2","description":["Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling"],"length":1103,"sequence":"MFTLPQKDSGTPTTCPGSVSTQGLHSNHGDGLERECSRKPDQKPLKLYGVGDPTAMFSSDSPYLSSRGSVIKWFWDSAEEGYRTYHMDEYDEEKNPSGIINLGTSENKLCFDLLSRRLSQSDMLRVELSLLQYPDWRGHLFLREEVARFLSFYCRSPTPLKPENVVVLNGCASLFSALATVLCEVGEAFLIPAPYYGAITQHVYLYGNVRLVCVYLDSEVTGLETRPFQLTVEKLEMALEGANSEGVKVKGLILINPQNPLGDVYSPGELQEYLKFAKRHELHVMVDEVYMLSVFEESVEYHSVLSLERLPDPQRTHVMWATSKDFGMSGLRFGTLYTENQDVATAVSSLCRYHGLSGLLQYQMAQLLRDRDWINQVYLPENRARLKAAHVYVSGELRALGIPFVSRGAGFFIWVDLRKECEEEALWVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGVFQFWPHSIESSSDWSVQKRSIRDVPVVRLPADSPVPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYSLKKYVDDAGVPVSSTISQEYNELLTAVSDSDYYTEDITRACLFIPSIDLLNQNALRVKETAQALAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVELPEKGPGPRRYFLLSSQMALHPEYREELAALQARHGEAALVLDKCTNLSEGIPAARKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLRAGCVPVIIADSYILPFSEVLDWKRASVAVPEEKMSDVYSILQSIPQRQIEEMQRQKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL","proteome":"UP000248484","gene":"LOC102979294","go_terms":[{"identifier":"GO:0030170","name":"pyridoxal phosphate binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009058","name":"biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016757","name":"glycosyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0009101","name":"glycoprotein biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4a539015c239d48852cf3ec80341430434cf47bf","counters":{"domain_architectures":23,"entries":19,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":3,"cdd":1,"pfam":3,"panther":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":23}}}