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{
    "metadata": {
        "accession": "A0A3Q2HBB4",
        "id": "A0A3Q2HBB4_HORSE",
        "source_organism": {
            "taxId": "9796",
            "scientificName": "Equus caballus",
            "fullName": "Equus caballus (Horse)"
        },
        "name": "Phosphodiesterase",
        "description": [
            "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine"
        ],
        "length": 837,
        "sequence": "MGCAPSIHISESRAAGPGGKEAEDAPGPAAPPPPPPPPGGPCLLTGQKTPAAPGARGASLAEPELGGGKKVAVADVQFGPMRFHPHQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKQHDIIIIDHRNPRQLDAEALCRSIRSSELSENTVIVGVVRRVDREESSVMPLIAAGFTRRYVENPSLMACYNELLQLEFGEVRSQLKLRACNSIFTALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVVGQGGKIRHYVSIIRVCNGNNKAEKITECVQSDSHTDNQSGKHKDRRKSSLDVRAVASRASEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHASDLVGGLMSDGLRRLSGNEYVLSTKNLQQVSSSMITPISLHDVPPRIARAMENEECWHFDIFELEAATHQRPLIYLGLKIFARFGICEFLNCSETTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLCRERIKQTLDPVDEAAALIAATVHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNLGRNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLAALEENGETDKDQEAINTMLRTPENRTLIKRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKRQDLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDEMKLRSLRPPPE",
        "proteome": "UP000002281",
        "gene": "PDE8A",
        "go_terms": [
            {
                "identifier": "GO:0004114",
                "name": "3',5'-cyclic-nucleotide phosphodiesterase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007165",
                "name": "signal transduction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0008081",
                "name": "phosphoric diester hydrolase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "ed58b5544390d0c8d7eff36891c67e45fc5182c6",
        "counters": {
            "domain_architectures": 612,
            "entries": 30,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 5,
                "cathgene3d": 3,
                "profile": 2,
                "smart": 2,
                "ncbifam": 1,
                "ssf": 2,
                "cdd": 2,
                "panther": 1,
                "prints": 1,
                "prosite": 1,
                "interpro": 10
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 612
        }
    }
}