{"metadata":{"accession":"A0A3Q2HBB4","id":"A0A3Q2HBB4_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"Phosphodiesterase","description":["Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine"],"length":837,"sequence":"MGCAPSIHISESRAAGPGGKEAEDAPGPAAPPPPPPPPGGPCLLTGQKTPAAPGARGASLAEPELGGGKKVAVADVQFGPMRFHPHQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKQHDIIIIDHRNPRQLDAEALCRSIRSSELSENTVIVGVVRRVDREESSVMPLIAAGFTRRYVENPSLMACYNELLQLEFGEVRSQLKLRACNSIFTALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVVGQGGKIRHYVSIIRVCNGNNKAEKITECVQSDSHTDNQSGKHKDRRKSSLDVRAVASRASEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHASDLVGGLMSDGLRRLSGNEYVLSTKNLQQVSSSMITPISLHDVPPRIARAMENEECWHFDIFELEAATHQRPLIYLGLKIFARFGICEFLNCSETTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLCRERIKQTLDPVDEAAALIAATVHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNLGRNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLAALEENGETDKDQEAINTMLRTPENRTLIKRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKRQDLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDEMKLRSLRPPPE","proteome":"UP000002281","gene":"PDE8A","go_terms":[{"identifier":"GO:0004114","name":"3',5'-cyclic-nucleotide phosphodiesterase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ed58b5544390d0c8d7eff36891c67e45fc5182c6","counters":{"domain_architectures":612,"entries":30,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"pfam":5,"cathgene3d":3,"profile":2,"smart":2,"ncbifam":1,"ssf":2,"cdd":2,"panther":1,"prints":1,"prosite":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":612}}}