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{
    "metadata": {
        "accession": "A0A397HK89",
        "id": "ANKE_ASPTH",
        "source_organism": {
            "taxId": "41047",
            "scientificName": "Aspergillus thermomutatus",
            "fullName": "Aspergillus thermomutatus"
        },
        "name": "NRPS-independent siderophore synthetase-like protein ankE",
        "description": [
            "NRPS-independent siderophore synthetase-like protein; part of the ank cluster that mediates the biosynthesis of NK13650 C, a highly modified cyclo-arginine-tyrosine dipeptide (PubMed:36702957). AnkE is responsible of the production of NK13650 B via ligation of citrate to the ankD product (PubMed:36702957). Within the pathway, the cyclodipeptide synthase ankA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Tyr diketopiperazine (cRY) from L-Arg and L-Tyr. The ankA product cRY is desaturated by the cytochrome P450 monooxygenase ankB to yield a dehydro-cyclodipeptide intermediate. The FAD-dependent monooxygenase ankC then installs the m-OH, ankD catalyzes the attachment of L-homoserine, and ankE ligates citrate to the ankD product to yield NK13650 B. The O-methyltransferase ankF is responsible for methylation of the C-17 phenol group of NK13650 B to produce NK13650 D. Amidation of NK13650 D with L-Asp by ankG then leads to the production of NK13650 C, whereas amidation of NK13650 B produces NK13650 A (PubMed:36702957)"
        ],
        "length": 604,
        "sequence": "MTVPPISERASFEVAKRLLCQILNEGLVSGTLETFESEEPYLCLFRNSCNTEKPEKCIRVRLQPSAQAGIFMRSARIVSLVRPEMLQMPVTLVDGTSERRELRSGALFQFASSLFTEHVEASTLEEIALGLENSEANTEKWLELHSSPGPLDLNSPSVLWERALIWGHPTHPFHRLCYAQEGLAPVEPRDLPEFLTPTLAFVSVLRDEISISGPFEESLQPLLAQLDVPAPETADRVVVPCLRLQLPCVFRHFPSAVLVKTVSGCADTQASMRTLTLRPELNFPYHIKLSIACQITSDVRAIRPCQTLGGQLVRKQLHEFFPPDLWWFKEVASVAGNQTAQGDTQENEDKARHIGCILREDLEARANANNEALIIAGSLAQQPANDPRTHAEIVFGLETVEQKHDWLKEYVAGFLRAVLPSLVQYGIGMEAHGQNALVRVCRDTRKITGFVVRDFEGIKVHVPTLEKLGINLCMTSPGCTKNLEDIWSKIHHSIFQNHLGNLVYALGLDRHDGWTIIRDELFAALKPDTDPRAKELYDFILQDTMPFKCFLRMRMSEHFNDYDGDEQDQPRVKRDERPLPNALLMGSARWEKVLNECAPKKLES",
        "proteome": "UP000215305",
        "gene": "ankE",
        "go_terms": [
            {
                "identifier": "GO:0019290",
                "name": "siderophore biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 1,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "4fd13fc20de0c23c20dba0905d0dcdeeaf05f543",
        "counters": {
            "domain_architectures": 12564,
            "entries": 7,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "panther": 1,
                "pfam": 2,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 12564
        }
    }
}