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{
    "metadata": {
        "accession": "A0A2Y9STY5",
        "id": "A0A2Y9STY5_PHYMC",
        "source_organism": {
            "taxId": "9755",
            "scientificName": "Physeter macrocephalus",
            "fullName": "Physeter macrocephalus (Sperm whale)"
        },
        "name": "Tuberin",
        "description": [
            "Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5"
        ],
        "length": 1822,
        "sequence": "MAKPASKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLNNRIRVIGQICEVAKTKKFEEAVSRCPVDRVGSCLPLEFLKGSALASTHFCHAVEALWKAVSDLLQPERPPEARHAVLALLKAIVQGQGDRLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAEFVLQWMDIGLSSEFLLVLVNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYHMCRIMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRRELQAVTWDILLKIVERLLQQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNELRSAVRIKVLDVLSFVLLINRQFYEEELINLVVISQLSHVPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVIARSLSPPPELEERDVVVYSASLEDVKTAVLGLLVILQTKLYALPASHATRVYETLVSHIQLHYKHTYTLPIASSIRLQAFDFLLQLRADSLHRLGLPSKDGLVRFSPYCVCDYMEPERGSEKKAGGPLSPPTGPPGPAPAVPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYKVLIFTSPCNVDQLSAALCSMLSGPKTLERLRSTPEGFSRTDLHLAVVPVLTALISYHNYLDKTRQREMVYCLEQGLIYRCASQCVVALAICSVEMPDIIIKALPVLVVKLTHISATASMAIPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAADAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQGGPELSSDPSVHVRQTKEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRVGALDAPASHFPGSPACLGSQTAPASKPEKASASTQLPAQKEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNTPLQELSNALMAAERFKERRDTALYKSLSVPAAGSAKPPPPPRSNTDSAVVLEEGSPGEASLPVEPPELEDFEATLGTDGHYRHAEAFSRSSSTSSQEEKSFHAEELAAGGIPIERAVSSEGSRPSVELAFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEAKARSQSGILDREGASWSAPGEESQGQGPTQPEGPLPSTCPRSPSGLRPRGYTISDSAPSRRGKRVERDAFRSRAGTSNTEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITPLDYECNLVSLQCRKDMEGLVDTSMAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDTYPSKWIARLRHIKRLRHRIREEAHYSNASLPLMQTHPPGHAKAPTQAPVEPTPTYETGQRKRLVSSVDDFTEFV",
        "proteome": "UP000248484",
        "gene": "TSC2",
        "go_terms": [
            {
                "identifier": "GO:0005096",
                "name": "GTPase activator activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0051056",
                "name": "regulation of small GTPase mediated signal transduction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0043547",
                "name": "positive regulation of GTPase activity",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0032007",
                "name": "negative regulation of TOR signaling",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0033596",
                "name": "TSC1-TSC2 complex",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "f74181c50b462dc72aee9d8137b7bec3a5d0e532",
        "counters": {
            "domain_architectures": 3654,
            "entries": 18,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 2,
                "cathgene3d": 2,
                "profile": 1,
                "pfam": 3,
                "panther": 1,
                "prints": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 3654
        }
    }
}