"accession"	"counters"	"description"	"gene"	"go_terms"	"id"	"ida_accession"	"in_alphafold"	"is_fragment"	"length"	"name"	"protein_evidence"	"proteome"	"sequence"	"source_database"	"source_organism"
"A0A2Y9STY5"	"{'domain_architectures': 3299, 'entries': 18, 'isoforms': 0, 'proteomes': 1, 'sets': 0, 'structures': 0, 'taxa': 1, 'dbEntries': {'ssf': 2, 'cathgene3d': 2, 'profile': 1, 'pfam': 3, 'panther': 1, 'prints': 1, 'interpro': 8}, 'proteome': 1, 'taxonomy': 1, 'similar_proteins': 3299}"	"['Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5']"	"TSC2"	"[{'identifier': 'GO:0005096', 'name': 'GTPase activator activity', 'category': {'code': 'F', 'name': 'molecular_function'}}, {'identifier': 'GO:0051056', 'name': 'regulation of small GTPase mediated signal transduction', 'category': {'code': 'P', 'name': 'biological_process'}}, {'identifier': 'GO:0043547', 'name': 'positive regulation of GTPase activity', 'category': {'code': 'P', 'name': 'biological_process'}}, {'identifier': 'GO:0005634', 'name': 'nucleus', 'category': {'code': 'C', 'name': 'cellular_component'}}, {'identifier': 'GO:0032007', 'name': 'negative regulation of TOR signaling', 'category': {'code': 'P', 'name': 'biological_process'}}, {'identifier': 'GO:0033596', 'name': 'TSC1-TSC2 complex', 'category': {'code': 'C', 'name': 'cellular_component'}}]"	"A0A2Y9STY5_PHYMC"	"f74181c50b462dc72aee9d8137b7bec3a5d0e532"	False	False	1822	"Tuberin"	4	"UP000248484"	"MAKPASKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLNNRIRVIGQICEVAKTKKFEEAVSRCPVDRVGSCLPLEFLKGSALASTHFCHAVEALWKAVSDLLQPERPPEARHAVLALLKAIVQGQGDRLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAEFVLQWMDIGLSSEFLLVLVNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYHMCRIMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRRELQAVTWDILLKIVERLLQQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNELRSAVRIKVLDVLSFVLLINRQFYEEELINLVVISQLSHVPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVIARSLSPPPELEERDVVVYSASLEDVKTAVLGLLVILQTKLYALPASHATRVYETLVSHIQLHYKHTYTLPIASSIRLQAFDFLLQLRADSLHRLGLPSKDGLVRFSPYCVCDYMEPERGSEKKAGGPLSPPTGPPGPAPAVPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYKVLIFTSPCNVDQLSAALCSMLSGPKTLERLRSTPEGFSRTDLHLAVVPVLTALISYHNYLDKTRQREMVYCLEQGLIYRCASQCVVALAICSVEMPDIIIKALPVLVVKLTHISATASMAIPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAADAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQGGPELSSDPSVHVRQTKEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRVGALDAPASHFPGSPACLGSQTAPASKPEKASASTQLPAQKEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNTPLQELSNALMAAERFKERRDTALYKSLSVPAAGSAKPPPPPRSNTDSAVVLEEGSPGEASLPVEPPELEDFEATLGTDGHYRHAEAFSRSSSTSSQEEKSFHAEELAAGGIPIERAVSSEGSRPSVELAFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEAKARSQSGILDREGASWSAPGEESQGQGPTQPEGPLPSTCPRSPSGLRPRGYTISDSAPSRRGKRVERDAFRSRAGTSNTEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITPLDYECNLVSLQCRKDMEGLVDTSMAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDTYPSKWIARLRHIKRLRHRIREEAHYSNASLPLMQTHPPGHAKAPTQAPVEPTPTYETGQRKRLVSSVDDFTEFV"	"unreviewed"	"{'taxId': '9755', 'scientificName': 'Physeter macrocephalus', 'fullName': 'Physeter macrocephalus (Sperm whale)'}"