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{
    "metadata": {
        "accession": "A0A2Y9RDY7",
        "id": "A0A2Y9RDY7_TRIMA",
        "source_organism": {
            "taxId": "127582",
            "scientificName": "Trichechus manatus latirostris",
            "fullName": "Trichechus manatus latirostris (Florida manatee)"
        },
        "name": "Paracaspase",
        "description": [
            "Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity"
        ],
        "length": 718,
        "sequence": "MSLWGEPQQAPQPSASQLPPTAPAGPPPPPPASATLNRLREPLLRRLSESLDRAPEGRGWRRLAEVAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKIIINPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPYGNSPELVFNTVHVKDSGFYVCRVNNNCTFEFSQWSQLDVCDVTENSRRSLDGVSESKLQICVEPTSQRLRPGKTLVLQCVAVGSPIPHYQWFRNESPLTHETKKLYVVPCVDLEHQGTYWCRVCNDRDTQDSRKVEIIVDELNNLGHPDNRDQTTDQPLAKDKVALLIGNMNYWEHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTESEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCYLTKGKQALEIRSSLSEKRALTDPIQGTACSAESLVRNLQWAKAHELPESMCLKFQCGVQIQLGFAAEFSNVMIIYTSIVHKPPEIIMCDAYVTDFPLDLDIDPKYANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKDNSPSPNMGKGTSSLHSMFIISVFRIGRDCRGKAGGECWEASHC",
        "proteome": "UP000248480",
        "gene": "MALT1",
        "go_terms": [
            {
                "identifier": "GO:0004197",
                "name": "cysteine-type endopeptidase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006508",
                "name": "proteolysis",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "80f0bcb0fea94b82186eabcd43c278d1fa4f1a75",
        "counters": {
            "domain_architectures": 548,
            "entries": 31,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 3,
                "cathgene3d": 4,
                "cdd": 2,
                "profile": 2,
                "pfam": 4,
                "smart": 2,
                "panther": 1,
                "interpro": 13
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 548
        }
    }
}