{"metadata":{"accession":"A0A2Y9RDY7","id":"A0A2Y9RDY7_TRIMA","source_organism":{"taxId":"127582","scientificName":"Trichechus manatus latirostris","fullName":"Trichechus manatus latirostris (Florida manatee)"},"name":"Paracaspase","description":["Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity"],"length":718,"sequence":"MSLWGEPQQAPQPSASQLPPTAPAGPPPPPPASATLNRLREPLLRRLSESLDRAPEGRGWRRLAEVAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKIIINPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPYGNSPELVFNTVHVKDSGFYVCRVNNNCTFEFSQWSQLDVCDVTENSRRSLDGVSESKLQICVEPTSQRLRPGKTLVLQCVAVGSPIPHYQWFRNESPLTHETKKLYVVPCVDLEHQGTYWCRVCNDRDTQDSRKVEIIVDELNNLGHPDNRDQTTDQPLAKDKVALLIGNMNYWEHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTESEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCYLTKGKQALEIRSSLSEKRALTDPIQGTACSAESLVRNLQWAKAHELPESMCLKFQCGVQIQLGFAAEFSNVMIIYTSIVHKPPEIIMCDAYVTDFPLDLDIDPKYANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKDNSPSPNMGKGTSSLHSMFIISVFRIGRDCRGKAGGECWEASHC","proteome":"UP000248480","gene":"MALT1","go_terms":[{"identifier":"GO:0004197","name":"cysteine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"80f0bcb0fea94b82186eabcd43c278d1fa4f1a75","counters":{"domain_architectures":497,"entries":31,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"ssf":3,"cathgene3d":4,"cdd":2,"profile":2,"pfam":4,"smart":2,"panther":1,"interpro":13},"proteome":1,"taxonomy":1,"similar_proteins":497}}}