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{
    "metadata": {
        "accession": "A0A2Y9R0N0",
        "id": "A0A2Y9R0N0_TRIMA",
        "source_organism": {
            "taxId": "127582",
            "scientificName": "Trichechus manatus latirostris",
            "fullName": "Trichechus manatus latirostris (Florida manatee)"
        },
        "name": "Polyamine-transporting ATPase 13A2",
        "description": [
            "ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis"
        ],
        "length": 1179,
        "sequence": "MSARSRHERSNPLVGNSPARYGTLMIETSVDPLSSSVSSMRLSGYCGGSPWRVIGYHIVVWMMAGIPLLLFRWKPMWGVQLRLRPCSLARAETLVIEIRDKEDSSWQRYIVQVQTEAISEGSLDLPPQAQMEDGRSQAAVGAVPEGSWKDTAQLHRKEEAKRVLRYYLFQGQRYVWIETQQAFCQVSMLDRGHTCDDIHRSQSGLSLQDQTVRKTIYGPNEITVPVKSYLQLLVDEALNPFYGFQAFSIMLWLADRYYWYALCIFLISAISICLSLYKTRKQSQKLRDMVKLSMQVCVYRPGGEEEWVDSRELVPGDCLVLPQEGGLMPCDAALVAGECIVNESCLTGESIPVLKTVLPEGPVPYCPETHRRHTLFCGTLVLQAQAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFIAALSVLAVLGTIYSIFILHRNQVPLKEIVIRALDLVTVVVPPALPAAMTVCTLYAQNRLQKQGIFCIHPPRIILGGKLRLVCFDKTGTLTEDGLDVMGVVPLQGQTFLPLDPEPRHLPMGPLLRALATCHTLSQLRDTPVGDPMDLKMVESTGWVLEGAPAADSTFGTQVLAVMRPPLGEPQLQEEPPVPVSILCRFPFSSTLQRMAVVVTWPRATQPEAYVKGSPELVSGLCRPETVPTNFAQTLQSYTAAGYRVIALASKPLPIAPNLEAAQQLTRDTMEQDLSLLGLLVMRNLLKPQTTPVIQALRRTHIRAVMVTGDNLQTAITVARGCSMVGPQEHLVIVHAIPPEQGQPASLEFLPVESSAAVNGTKDPGQAVSCTMELDPRSSHLALSGSTFTILVKHFPKLLPKVLVQGTIFARMTPEQKTKLVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSSFTSSAASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDMQFLTIDLVITSTVAVLMSRTGPALVLGRARPPGALLSVPVLCSLLLQVALVAGVQLGGYFLTMAQPWFVPLNRTVPAPDNLPNYENTVIFSLSSFQYLILASAMSKGAPFRQPLYTNVPFLVALVLLSSFLAGLILVPSPLYRILALRNISDICFRLLLLGLVAFNFVAAFMLESMLDQYLPACLRRLRPKQASKKRFKQLERELTEQPWPPLPADPVR",
        "proteome": "UP000248480",
        "gene": "ATP13A2",
        "go_terms": [
            {
                "identifier": "GO:0015662",
                "name": "P-type ion transporter activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0019829",
                "name": "ATPase-coupled monoatomic cation transmembrane transporter activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0000166",
                "name": "nucleotide binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0140358",
                "name": "P-type transmembrane transporter activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0005215",
                "name": "transporter activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016887",
                "name": "ATP hydrolysis activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "ce80787ecdfa3a875a099834cb38cf61f0f0397a",
        "counters": {
            "domain_architectures": 3762,
            "entries": 34,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 4,
                "cathgene3d": 4,
                "pfam": 4,
                "cdd": 1,
                "ncbifam": 2,
                "panther": 1,
                "sfld": 3,
                "prosite": 1,
                "prints": 1,
                "interpro": 13
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 3762
        }
    }
}