{"metadata":{"accession":"A0A2Y9R0N0","id":"A0A2Y9R0N0_TRIMA","source_organism":{"taxId":"127582","scientificName":"Trichechus manatus latirostris","fullName":"Trichechus manatus latirostris (Florida manatee)"},"name":"Polyamine-transporting ATPase 13A2","description":["ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis"],"length":1179,"sequence":"MSARSRHERSNPLVGNSPARYGTLMIETSVDPLSSSVSSMRLSGYCGGSPWRVIGYHIVVWMMAGIPLLLFRWKPMWGVQLRLRPCSLARAETLVIEIRDKEDSSWQRYIVQVQTEAISEGSLDLPPQAQMEDGRSQAAVGAVPEGSWKDTAQLHRKEEAKRVLRYYLFQGQRYVWIETQQAFCQVSMLDRGHTCDDIHRSQSGLSLQDQTVRKTIYGPNEITVPVKSYLQLLVDEALNPFYGFQAFSIMLWLADRYYWYALCIFLISAISICLSLYKTRKQSQKLRDMVKLSMQVCVYRPGGEEEWVDSRELVPGDCLVLPQEGGLMPCDAALVAGECIVNESCLTGESIPVLKTVLPEGPVPYCPETHRRHTLFCGTLVLQAQAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFIAALSVLAVLGTIYSIFILHRNQVPLKEIVIRALDLVTVVVPPALPAAMTVCTLYAQNRLQKQGIFCIHPPRIILGGKLRLVCFDKTGTLTEDGLDVMGVVPLQGQTFLPLDPEPRHLPMGPLLRALATCHTLSQLRDTPVGDPMDLKMVESTGWVLEGAPAADSTFGTQVLAVMRPPLGEPQLQEEPPVPVSILCRFPFSSTLQRMAVVVTWPRATQPEAYVKGSPELVSGLCRPETVPTNFAQTLQSYTAAGYRVIALASKPLPIAPNLEAAQQLTRDTMEQDLSLLGLLVMRNLLKPQTTPVIQALRRTHIRAVMVTGDNLQTAITVARGCSMVGPQEHLVIVHAIPPEQGQPASLEFLPVESSAAVNGTKDPGQAVSCTMELDPRSSHLALSGSTFTILVKHFPKLLPKVLVQGTIFARMTPEQKTKLVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSSFTSSAASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDMQFLTIDLVITSTVAVLMSRTGPALVLGRARPPGALLSVPVLCSLLLQVALVAGVQLGGYFLTMAQPWFVPLNRTVPAPDNLPNYENTVIFSLSSFQYLILASAMSKGAPFRQPLYTNVPFLVALVLLSSFLAGLILVPSPLYRILALRNISDICFRLLLLGLVAFNFVAAFMLESMLDQYLPACLRRLRPKQASKKRFKQLERELTEQPWPPLPADPVR","proteome":"UP000248480","gene":"ATP13A2","go_terms":[{"identifier":"GO:0015662","name":"P-type ion transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019829","name":"ATPase-coupled monoatomic cation transmembrane transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000166","name":"nucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0140358","name":"P-type transmembrane transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005215","name":"transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016887","name":"ATP hydrolysis activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ce80787ecdfa3a875a099834cb38cf61f0f0397a","counters":{"domain_architectures":3762,"entries":34,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":4,"cathgene3d":4,"pfam":4,"cdd":1,"ncbifam":2,"panther":1,"sfld":3,"prosite":1,"prints":1,"interpro":13},"proteome":1,"taxonomy":1,"similar_proteins":3762}}}