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{
    "metadata": {
        "accession": "A0A2S1Z2A4",
        "id": "A0A2S1Z2A4_9ACTN",
        "source_organism": {
            "taxId": "1690221",
            "scientificName": "Streptomyces spongiicola",
            "fullName": "Streptomyces spongiicola"
        },
        "name": "DNA integrity scanning protein DisA",
        "description": [
            "Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis",
            "Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation"
        ],
        "length": 377,
        "sequence": "MAANDRGSAPGKSGGGPGGSGTDALMRASLSAVAPGTALRDGLERILRGSTGGLIVLGMDKSVESMCTGGFVLDVEFTATRLRELCKLDGALILDKDITKIHRAGVQLVPDASIPTEETGTRHRTADRVSKQCGFPVVSVSQSMRLIALYVDGERRVLEESAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVTAVAQRLEMVRRIATEIEQYVVELGTDGRLLALQLDELIAGVEPERGLVVRDYVPEPTAKRSRTVDEALAELNDLTHAELLELPIVARALGYSGSPETLDSAVSPRGYRLLAKVPRLPGAIIERLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV",
        "proteome": "UP000245051",
        "gene": "disA",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "08a5f02a21da192673f012aeda45116378e4a92a",
        "counters": {
            "domain_architectures": 1266,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 1,
                "cathgene3d": 3,
                "ssf": 2,
                "pfam": 3,
                "hamap": 1,
                "ncbifam": 1,
                "panther": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1266
        }
    }
}