{"metadata":{"accession":"A0A2S1Z2A4","id":"A0A2S1Z2A4_9ACTN","source_organism":{"taxId":"1690221","scientificName":"Streptomyces spongiicola","fullName":"Streptomyces spongiicola"},"name":"DNA integrity scanning protein DisA","description":["Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis","Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation"],"length":377,"sequence":"MAANDRGSAPGKSGGGPGGSGTDALMRASLSAVAPGTALRDGLERILRGSTGGLIVLGMDKSVESMCTGGFVLDVEFTATRLRELCKLDGALILDKDITKIHRAGVQLVPDASIPTEETGTRHRTADRVSKQCGFPVVSVSQSMRLIALYVDGERRVLEESAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVTAVAQRLEMVRRIATEIEQYVVELGTDGRLLALQLDELIAGVEPERGLVVRDYVPEPTAKRSRTVDEALAELNDLTHAELLELPIVARALGYSGSPETLDSAVSPRGYRLLAKVPRLPGAIIERLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV","proteome":"UP000245051","gene":"disA","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"08a5f02a21da192673f012aeda45116378e4a92a","counters":{"domain_architectures":1266,"entries":20,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":3,"ssf":2,"pfam":3,"hamap":1,"ncbifam":1,"panther":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":1266}}}