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{
    "metadata": {
        "accession": "A0A218V3U1",
        "id": "A0A218V3U1_9PASE",
        "source_organism": {
            "taxId": "40157",
            "scientificName": "Lonchura striata",
            "fullName": "Lonchura striata (white-rumped munia)"
        },
        "name": "OTU domain-containing protein 4",
        "description": [
            "Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions"
        ],
        "length": 1130,
        "sequence": "MDAAGRAGGGEQSHPGSDAPGDTSMDRYLRSQGLYRKKVAKDGSCLFRAVAEQVLHSQSRHIDVRMACVDYLRKNREKFEAFIEGPFEDYLKSLENPQEWVGQVEISALSLMYKKDFIIYQEPNASPSHVTENGFSDKVLLCFSSGNHYDIVYPIEYAEKAALCQSLLYELLYEKVFDMDVKKIMAERGAVGVTEESNGSSEVSASDSEDDNYRSKATTVSDMNGMKSLSGNKHLESNGNPTSLALPKKVLKSLDPLVYRNIEYDVWLRSKWDQQKQDFSIAAGMQYSIGDKCKVRLDHNGKFYNAHIQEVCSENGPVVVFVEELGAKHAVSLKSLKPLPQTSPMEGWNTVPGKKIKKFYPAWGQNAQPDAECRGPKNQSKSIKPQSALPPRLQHTVGTRQHQFLGSGPQPHQTSNEQKTPGRNPSQSARKVERERSEELSHGSRDCNYFGLSPEERREKQAIEESRSLYEIQQRDEQAFPALCNNQLVCQAATQTVDNVNQKKFSNSERRNSKWTAEVEEQKEKESNSRQIHLSQKLEPNSSEKNSQDESYPKASSPLEQVKTDSPIVAEQVRNVCLISKFSSQETSDKGELHHSHNLTECLPSVTPTPSPVFSEVHLPPAVPSVPAIVPAWPSEPATYGPAGIPTQIPASSLMPGPATGPDSIVSQAQTLNPYQDPLYPGFPFNEKGERAVAPPYSLCSTGEDLPKDKNILRFFFNLGVKAYSCPMWAPHSYLYPLHQAYLAACRMYPNVSLPVYPHNPWFQEAAPAQNENETARPNRHFAVQTEARSNGQIPQVDRSPSLPLIIPSAQVTESQGQVCVEPENPAQALHANYEESLRGKNMFPQPPFGHNHFLGAVPIAPPFFPHFWYGYPVQGFIENSVARPNLVLSPEDKEAAAGTSASMYVGKECSPPVPGVNCAEQLQKTNSGSGPNTVPFAVAAAGTPKDTSARAPQLEQTCPSATPKQKAAGQQHRSPQTQGPERPTAGPGTQPLLAEPPKNELKPSTPGRKERPAKGRESKGAGNVQMESRAQRTREESSEDDTEVSDMLRSGRSKQFYSQTYGGGRRPRPDRGYSSRGGYQFQRNEEAWKGPPSRNRDDGYQYQRNFRGQSYRNDRRRATLGDNQRGQQA",
        "proteome": "UP000197619",
        "gene": "OTUD4",
        "go_terms": null,
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "0385c19cd1efb2670ef9513f5d43d80283d20182",
        "counters": {
            "domain_architectures": 22191,
            "entries": 15,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "cdd": 2,
                "profile": 2,
                "pfam": 1,
                "smart": 1,
                "panther": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 22191
        }
    }
}