{"metadata":{"accession":"A0A218V3U1","id":"A0A218V3U1_9PASE","source_organism":{"taxId":"40157","scientificName":"Lonchura striata","fullName":"Lonchura striata (white-rumped munia)"},"name":"OTU domain-containing protein 4","description":["Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions"],"length":1130,"sequence":"MDAAGRAGGGEQSHPGSDAPGDTSMDRYLRSQGLYRKKVAKDGSCLFRAVAEQVLHSQSRHIDVRMACVDYLRKNREKFEAFIEGPFEDYLKSLENPQEWVGQVEISALSLMYKKDFIIYQEPNASPSHVTENGFSDKVLLCFSSGNHYDIVYPIEYAEKAALCQSLLYELLYEKVFDMDVKKIMAERGAVGVTEESNGSSEVSASDSEDDNYRSKATTVSDMNGMKSLSGNKHLESNGNPTSLALPKKVLKSLDPLVYRNIEYDVWLRSKWDQQKQDFSIAAGMQYSIGDKCKVRLDHNGKFYNAHIQEVCSENGPVVVFVEELGAKHAVSLKSLKPLPQTSPMEGWNTVPGKKIKKFYPAWGQNAQPDAECRGPKNQSKSIKPQSALPPRLQHTVGTRQHQFLGSGPQPHQTSNEQKTPGRNPSQSARKVERERSEELSHGSRDCNYFGLSPEERREKQAIEESRSLYEIQQRDEQAFPALCNNQLVCQAATQTVDNVNQKKFSNSERRNSKWTAEVEEQKEKESNSRQIHLSQKLEPNSSEKNSQDESYPKASSPLEQVKTDSPIVAEQVRNVCLISKFSSQETSDKGELHHSHNLTECLPSVTPTPSPVFSEVHLPPAVPSVPAIVPAWPSEPATYGPAGIPTQIPASSLMPGPATGPDSIVSQAQTLNPYQDPLYPGFPFNEKGERAVAPPYSLCSTGEDLPKDKNILRFFFNLGVKAYSCPMWAPHSYLYPLHQAYLAACRMYPNVSLPVYPHNPWFQEAAPAQNENETARPNRHFAVQTEARSNGQIPQVDRSPSLPLIIPSAQVTESQGQVCVEPENPAQALHANYEESLRGKNMFPQPPFGHNHFLGAVPIAPPFFPHFWYGYPVQGFIENSVARPNLVLSPEDKEAAAGTSASMYVGKECSPPVPGVNCAEQLQKTNSGSGPNTVPFAVAAAGTPKDTSARAPQLEQTCPSATPKQKAAGQQHRSPQTQGPERPTAGPGTQPLLAEPPKNELKPSTPGRKERPAKGRESKGAGNVQMESRAQRTREESSEDDTEVSDMLRSGRSKQFYSQTYGGGRRPRPDRGYSSRGGYQFQRNEEAWKGPPSRNRDDGYQYQRNFRGQSYRNDRRRATLGDNQRGQQA","proteome":"UP000197619","gene":"OTUD4","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0385c19cd1efb2670ef9513f5d43d80283d20182","counters":{"domain_architectures":22191,"entries":15,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":2,"profile":2,"pfam":1,"smart":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":22191}}}