General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A1U7TA82",
        "id": "A0A1U7TA82_CARSF",
        "source_organism": {
            "taxId": "1868482",
            "scientificName": "Carlito syrichta",
            "fullName": "Carlito syrichta (Philippine tarsier)"
        },
        "name": "Ubiquitin-like modifier-activating enzyme 5",
        "description": [
            "E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes"
        ],
        "length": 367,
        "sequence": "MIAFGCLFSLTMCIYLVTTNWKIVSFKTFFFVLSRLMALKRMGIVSNYEKIRTFAVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVLFEVYDYNITTVDNFQHFMGRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKSLKREGVCAASLPTTMAVVAGMLVQNVLKLLLNFGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQQEEYKKKVAALPKQEIVQEEEEIIHEDNEWGIELVSEVSEEELKNSSDPIPDLPAGITVAYTVPKKVHQKFDLPLS",
        "proteome": "UP000189704",
        "gene": "LOC103253324",
        "go_terms": [
            {
                "identifier": "GO:0008641",
                "name": "ubiquitin-like modifier activating enzyme activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": true,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "b1d92a185af293e4ec8b5b64afb0164bb6770d0f",
        "counters": {
            "domain_architectures": 60749,
            "entries": 10,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cdd": 1,
                "pfam": 1,
                "ssf": 1,
                "cathgene3d": 1,
                "panther": 1,
                "prosite": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 60749
        }
    }
}