{"metadata":{"accession":"A0A1U7TA82","id":"A0A1U7TA82_CARSF","source_organism":{"taxId":"1868482","scientificName":"Carlito syrichta","fullName":"Carlito syrichta (Philippine tarsier)"},"name":"Ubiquitin-like modifier-activating enzyme 5","description":["E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes"],"length":367,"sequence":"MIAFGCLFSLTMCIYLVTTNWKIVSFKTFFFVLSRLMALKRMGIVSNYEKIRTFAVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVLFEVYDYNITTVDNFQHFMGRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKSLKREGVCAASLPTTMAVVAGMLVQNVLKLLLNFGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQQEEYKKKVAALPKQEIVQEEEEIIHEDNEWGIELVSEVSEEELKNSSDPIPDLPAGITVAYTVPKKVHQKFDLPLS","proteome":"UP000189704","gene":"LOC103253324","go_terms":[{"identifier":"GO:0008641","name":"ubiquitin-like modifier activating enzyme activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"ida_accession":"b1d92a185af293e4ec8b5b64afb0164bb6770d0f","counters":{"domain_architectures":42420,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"pfam":1,"ssf":1,"cathgene3d":1,"panther":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":42420}}}