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InterPro-Version: 108.0
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{
"metadata": {
"accession": "A0A1A8V4R9",
"id": "A0A1A8V4R9_NOTFU",
"source_organism": {
"taxId": "105023",
"scientificName": "Nothobranchius furzeri",
"fullName": "Nothobranchius furzeri (Turquoise killifish)"
},
"name": "RRM domain-containing protein",
"description": [
"Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing"
],
"length": 317,
"sequence": "MDRSSSSSLMASSNVTNKTDPRSLNSRVFIGNLNTLLVTKADVEAIFAKYGKIVGCSVHKGYAFVQFSNERNARAAVAGEDGRMIVGQVLDINLAGEPKPHRSKTTKRSAGDMYSSSSSFDLDYDFQRDYYDRMYSYPSRVPAPPPPLSRAVIPSKRPRVSLSGGSSRRNKSSFSSSKSSQRTSSRTMRADELQTIKRELTQIKSKVDDLLESLERMEKDHIKKSVKNMKTEPGEVTSPPHSSSKKDDGLKRDRESHNMNNSDEDDDEEDEGDLLEEEEVKSQEREEEEEEEEEEGEHVEGDDDDDDGDSVNGDDDS",
"proteome": "UP000694548",
"gene": "Nfu_g_1_013226",
"go_terms": [
{
"identifier": "GO:0003676",
"name": "nucleic acid binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003723",
"name": "RNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006260",
"name": "DNA replication",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005634",
"name": "nucleus",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0043625",
"name": "delta DNA polymerase complex",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "f204fb6a444d7e78db6afaad28d0f4607943fd9d",
"counters": {
"domain_architectures": 10,
"entries": 15,
"isoforms": 0,
"proteomes": 1,
"sets": 3,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 1,
"ssf": 1,
"cdd": 1,
"profile": 1,
"smart": 1,
"pfam": 2,
"pirsf": 1,
"panther": 1,
"interpro": 6
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 10
}
}
}