{"metadata":{"accession":"A0A1A8V4R9","id":"A0A1A8V4R9_NOTFU","source_organism":{"taxId":"105023","scientificName":"Nothobranchius furzeri","fullName":"Nothobranchius furzeri (Turquoise killifish)"},"name":"RRM domain-containing protein","description":["Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing"],"length":317,"sequence":"MDRSSSSSLMASSNVTNKTDPRSLNSRVFIGNLNTLLVTKADVEAIFAKYGKIVGCSVHKGYAFVQFSNERNARAAVAGEDGRMIVGQVLDINLAGEPKPHRSKTTKRSAGDMYSSSSSFDLDYDFQRDYYDRMYSYPSRVPAPPPPLSRAVIPSKRPRVSLSGGSSRRNKSSFSSSKSSQRTSSRTMRADELQTIKRELTQIKSKVDDLLESLERMEKDHIKKSVKNMKTEPGEVTSPPHSSSKKDDGLKRDRESHNMNNSDEDDDEEDEGDLLEEEEVKSQEREEEEEEEEEEGEHVEGDDDDDDGDSVNGDDDS","proteome":"UP000694548","gene":"hnrnpc","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006260","name":"DNA replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0043625","name":"delta DNA polymerase complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"f204fb6a444d7e78db6afaad28d0f4607943fd9d","counters":{"domain_architectures":5,"entries":15,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"profile":1,"smart":1,"pfam":2,"pirsf":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":5}}}