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{
    "metadata": {
        "accession": "A0A091G9G3",
        "id": "A0A091G9G3_CUCCA",
        "source_organism": {
            "taxId": "55661",
            "scientificName": "Cuculus canorus",
            "fullName": "Cuculus canorus (Common cuckoo)"
        },
        "name": "[histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase",
        "description": [
            "Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes"
        ],
        "length": 820,
        "sequence": "MSTGRLRMKKKACSSDQSPDNLPLRSSGRQVKKKAAEAADDDDEASEKKYRKCEKAGCTATCPVCFASAAERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYEKYTAWKRIWTSNGKSEPSPKAFMADQQLPYWVQCTKPDCGKWRQLTKEIQLTPQIAKTYRCGMKLNNSTKTEGSDQCSMPEDLRVAEVSDHWWYSMLILPPLLKDSVAAPFLAAYYPDCVGMSPSCTSTNRLPGESNLVKLEHLKSVPNLTVAGMNKYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIHHIIVRGLVRIRCVQEMERILYFMTRKGLINTGILSVSPDQYLLPKEYHNKSVIIVGAGAAGLGAARQLHNFGIKVIVLEAKDRIGGRVWDDKTFNGVTVGRGAQIVNGCVNNPVALMCEQLGIKMHKLGEKCDLIQEGGRITDPTIDKRMDFHFNAILDVVSEWRKDKTQHHDVPLGEKIQEIYKAFIQESGIQFSELEEKVLQFHLSNLEYACGSNLSQVSARSWDHNEFFAQFAGDHTLLTVGYSTVIDKLAEGLDIRLNFPVQSIDYSGEEVQVTTADGTVWTTQKVLVTVPLALLQKNAIQFNPPLSEKKIKAINSLGAGVIEKIALEFPYRFWDSKIQGADFFGHVPPNSSLRGLFSVFYDIDPERKQSILMSVVTGDAVTTIKNLDDKQVLQQCMTVLRELFKEQEVPDPVKFFVTRWREDPWLQMAYSFVKTGGTGEAYDIIAEDIQGKIFFAGEATNRHFPQTVTGAYLSGVREASKIAAF",
        "proteome": "UP000053760",
        "gene": "N303_07719",
        "go_terms": [
            {
                "identifier": "GO:0008270",
                "name": "zinc ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016491",
                "name": "oxidoreductase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "bba4664c4b0765da687f8415dc7e10b5ed45c81d",
        "counters": {
            "domain_architectures": 922,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 4,
                "profile": 2,
                "pfam": 3,
                "ssf": 3,
                "panther": 1,
                "interpro": 7
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 922
        }
    }
}