{"metadata":{"accession":"A0A091G9G3","id":"A0A091G9G3_CUCCA","source_organism":{"taxId":"55661","scientificName":"Cuculus canorus","fullName":"Cuculus canorus (Common cuckoo)"},"name":"[histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase","description":["Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes"],"length":820,"sequence":"MSTGRLRMKKKACSSDQSPDNLPLRSSGRQVKKKAAEAADDDDEASEKKYRKCEKAGCTATCPVCFASAAERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYEKYTAWKRIWTSNGKSEPSPKAFMADQQLPYWVQCTKPDCGKWRQLTKEIQLTPQIAKTYRCGMKLNNSTKTEGSDQCSMPEDLRVAEVSDHWWYSMLILPPLLKDSVAAPFLAAYYPDCVGMSPSCTSTNRLPGESNLVKLEHLKSVPNLTVAGMNKYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIHHIIVRGLVRIRCVQEMERILYFMTRKGLINTGILSVSPDQYLLPKEYHNKSVIIVGAGAAGLGAARQLHNFGIKVIVLEAKDRIGGRVWDDKTFNGVTVGRGAQIVNGCVNNPVALMCEQLGIKMHKLGEKCDLIQEGGRITDPTIDKRMDFHFNAILDVVSEWRKDKTQHHDVPLGEKIQEIYKAFIQESGIQFSELEEKVLQFHLSNLEYACGSNLSQVSARSWDHNEFFAQFAGDHTLLTVGYSTVIDKLAEGLDIRLNFPVQSIDYSGEEVQVTTADGTVWTTQKVLVTVPLALLQKNAIQFNPPLSEKKIKAINSLGAGVIEKIALEFPYRFWDSKIQGADFFGHVPPNSSLRGLFSVFYDIDPERKQSILMSVVTGDAVTTIKNLDDKQVLQQCMTVLRELFKEQEVPDPVKFFVTRWREDPWLQMAYSFVKTGGTGEAYDIIAEDIQGKIFFAGEATNRHFPQTVTGAYLSGVREASKIAAF","proteome":"UP000053760","gene":"N303_07719","go_terms":[{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bba4664c4b0765da687f8415dc7e10b5ed45c81d","counters":{"domain_architectures":922,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"profile":2,"pfam":3,"ssf":3,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":922}}}