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{
    "metadata": {
        "accession": "A0A091FKR9",
        "id": "A0A091FKR9_CUCCA",
        "source_organism": {
            "taxId": "55661",
            "scientificName": "Cuculus canorus",
            "fullName": "Cuculus canorus (Common cuckoo)"
        },
        "name": "E3 ubiquitin-protein ligase NEURL1",
        "description": [
            "Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway"
        ],
        "length": 546,
        "sequence": "LSDSIGGSFSTSSHRCHHKQKHCLPIPQCGVLSISPLLFHPHTKGSQIIMDTTQKAVKRQASFCNAITFSNRPIVIYEQVRLKITKKQCCWSGALRLGFTSKDPSRINPDTLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRVNDSVAMLFFSGVRTAEPLWALIDVYGLTRGVQLLDSEIIPPDCLRPRSFTAIRRPSLRRETEDTRLSVSLCDLNLQEETFHMTATTCPIPQNSLNSQHSHLLPSQLESDLRFHHLRGPHVKILDDQTVARLEHAREERTLVFTSRPLRINETIFVKINKSNAVRMGTLSYGVTSCDPSTLRPSDLPYNPESLVDRKEFWAICRVVVPLQSGDILGFMVNSDGELHLSHNGAGTGMQVCVDCSQPLWMFFVLHGAVTQIRLLGSTVLAERLGLSTPSSPTSTPNSPTVLCSGVSDPILSTCGSGPLCSSISGTAPNSPISLPESPISPSVSGPWGDECTICYENMVDTVIYSCGHMCLCYSCGLKLKKMANACCPICRRAIKDIIKTYRST",
        "proteome": "UP000053760",
        "gene": "N303_01696",
        "go_terms": null,
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": true,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "e3a27e50abfe304b76b49507e3652379ac021640",
        "counters": {
            "domain_architectures": 2741,
            "entries": 14,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "smart": 1,
                "profile": 2,
                "pfam": 2,
                "cathgene3d": 2,
                "ssf": 1,
                "panther": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2741
        }
    }
}