{"metadata":{"accession":"A0A091FKR9","id":"A0A091FKR9_CUCCA","source_organism":{"taxId":"55661","scientificName":"Cuculus canorus","fullName":"Cuculus canorus (Common cuckoo)"},"name":"E3 ubiquitin-protein ligase NEURL1","description":["Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway"],"length":546,"sequence":"LSDSIGGSFSTSSHRCHHKQKHCLPIPQCGVLSISPLLFHPHTKGSQIIMDTTQKAVKRQASFCNAITFSNRPIVIYEQVRLKITKKQCCWSGALRLGFTSKDPSRINPDTLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRVNDSVAMLFFSGVRTAEPLWALIDVYGLTRGVQLLDSEIIPPDCLRPRSFTAIRRPSLRRETEDTRLSVSLCDLNLQEETFHMTATTCPIPQNSLNSQHSHLLPSQLESDLRFHHLRGPHVKILDDQTVARLEHAREERTLVFTSRPLRINETIFVKINKSNAVRMGTLSYGVTSCDPSTLRPSDLPYNPESLVDRKEFWAICRVVVPLQSGDILGFMVNSDGELHLSHNGAGTGMQVCVDCSQPLWMFFVLHGAVTQIRLLGSTVLAERLGLSTPSSPTSTPNSPTVLCSGVSDPILSTCGSGPLCSSISGTAPNSPISLPESPISPSVSGPWGDECTICYENMVDTVIYSCGHMCLCYSCGLKLKKMANACCPICRRAIKDIIKTYRST","proteome":"UP000053760","gene":"N303_01696","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e3a27e50abfe304b76b49507e3652379ac021640","counters":{"domain_architectures":2741,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"smart":1,"profile":2,"pfam":2,"cathgene3d":2,"ssf":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":2741}}}