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{
"metadata": {
"accession": "PS51800",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "profile",
"member_databases": null,
"integrated": "IPR022776",
"hierarchy": null,
"name": {
"name": "Zinc finger CHHC U11-48K-type profile",
"short": "ZF_CHHC_U11_48K"
},
"description": [
{
"text": "<p>The CHHC U11-48K-type zinc finger is found only in eukaryotes. It has been\nidentified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13\nand gametocyte specific factors (GTSF). The CHHC U11-48K-type zinc finger (~30\nresidues) is present in a single copy in U11-48k AND TRM13, whereas GTSF\ncontains two repeats separated by a short linker. The CHHC U11-48K-type zinc\nfinger may function as a RNA recognition and binding module [[cite:PUB00053822]][[cite:PUB00059781]].\n\nThe CHHC U11-48K-type zinc finger contains four invariant Cys and His residues\nwith a consensus sequence of C-x(5,7)-H-x(7,9)-H-x(3,4)-C. It\nstochiometrically binds zinc ions in a one-to-one ratio. The structure of the\nCHHC U11-48K-type zinc finger consists of a beta hairpin followed by a helix. the zinc ion is coordinated by Cys and His residues from the\nbeta hairpin and by His and Cys residues from the helix, respectively. The\nhelical region has an alpha-helical conformation that is interrupted in the\nmiddle by a single pi-helical turn [[cite:PUB00059781]].\n\nThe profile we developed covers the entire CHHC U11-48K-type zinc finger.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00053822": {
"PMID": 18703587,
"ISBN": null,
"volume": "24",
"issue": "20",
"year": 2008,
"title": "A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.",
"URL": null,
"raw_pages": "2277-80",
"medline_journal": "Bioinformatics",
"ISO_journal": "Bioinformatics",
"authors": [
"Andreeva A",
"Tidow H."
],
"DOI_URL": "http://dx.doi.org/10.1093/bioinformatics/btn431"
},
"PUB00059781": {
"PMID": 19217400,
"ISBN": null,
"volume": "17",
"issue": "2",
"year": 2009,
"title": "Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns.",
"URL": null,
"raw_pages": "294-302",
"medline_journal": "Structure",
"ISO_journal": "Structure",
"authors": [
"Tidow H",
"Andreeva A",
"Rutherford TJ",
"Fersht AR."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.str.2008.11.013"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 8800,
"pathways": 0,
"proteins": 6625,
"proteomes": 1921,
"sets": 0,
"structural_models": {
"alphafold": 6004,
"bfvd": 0
},
"structures": 12,
"taxa": 6218
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
