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{
"metadata": {
"accession": "PS51376",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "profile",
"member_databases": null,
"integrated": "IPR017893",
"hierarchy": null,
"name": {
"name": "DBB domain profile",
"short": "DBB"
},
"description": [
{
"text": "<p>The following proteins share a number of distinct parts, namely, ankyrin\nrepeats, a coiled coil, and a stretch of approximately 140\namino acid residues upstream of the ankyrin repeats, which has been called the\nDof/BCAP/BANK (DBB) domain [[cite:PUB00043704]][[cite:PUB00043705]]:\n\n - Drosophila Downstream-of-EGF receptor (Dof), a protein essential for the\n morphogenesis of both the mesoderm and the tracheae. It has been proposed\n to mediate the transmission of a signal from an activated receptor to other\n components of the cell, including the MAP kinase cascade.\n - Vertebrate BANK and BCAP proteins that function in B-cell signaling.\n\nThese proteins are involved in signaling; however, unlike Dof, BANK and BCAP\nare not implicated in FGF signaling but appear to have undergone rapid change\nduring the course of evolution to acquire a novel function with the\ndevelopment of the immune system in higher vertebrates.\n\nThe DBB domain in both Dof and BCAP is required to mediate self-association in\nyeast cells, indicating that this domain may have a more general role in\nmediating protein-protein interactions [[cite:PUB00043704]].\n\nThe profile we developed covers the entire DBB domain.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00043704": {
"PMID": 12767830,
"ISBN": null,
"volume": "329",
"issue": "3",
"year": 2003,
"title": "Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP.",
"URL": null,
"raw_pages": "479-93",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Battersby A",
"Csiszar A",
"Leptin M",
"Wilson R."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0022-2836(03)00489-3"
},
"PUB00043705": {
"PMID": 14993266,
"ISBN": null,
"volume": "24",
"issue": "6",
"year": 2004,
"title": "A functional domain of Dof that is required for fibroblast growth factor signaling.",
"URL": null,
"raw_pages": "2263-76",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Wilson R",
"Battersby A",
"Csiszar A",
"Vogelsang E",
"Leptin M."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.24.6.2263-2276.2004"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 2599,
"pathways": 0,
"proteins": 2598,
"proteomes": 1011,
"sets": 0,
"structural_models": {
"alphafold": 2230,
"bfvd": 0
},
"structures": 1,
"taxa": 3548
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
