{"metadata":{"accession":"PS51376","entry_id":null,"type":"domain","go_terms":null,"source_database":"profile","member_databases":null,"integrated":"IPR017893","hierarchy":null,"name":{"name":"DBB domain profile","short":"DBB"},"description":[{"text":"<p>The following proteins share a number of distinct parts, namely, ankyrin\nrepeats, a coiled coil, and a stretch of approximately 140\namino acid residues upstream of the ankyrin repeats, which has been called the\nDof/BCAP/BANK (DBB) domain [[cite:PUB00043704]][[cite:PUB00043705]]:\n\n - Drosophila  Downstream-of-EGF  receptor  (Dof), a protein essential for the\n   morphogenesis of  both  the mesoderm and the tracheae. It has been proposed\n   to mediate the transmission of a signal from an activated receptor to other\n   components of the cell, including the MAP kinase cascade.\n - Vertebrate BANK and BCAP proteins that function in B-cell signaling.\n\nThese proteins are involved in signaling; however, unlike Dof, BANK and BCAP\nare not implicated in FGF signaling but appear to have undergone rapid change\nduring the course of evolution to acquire a novel function with the\ndevelopment of the immune system in higher vertebrates.\n\nThe DBB domain in both Dof and BCAP is required to mediate self-association in\nyeast cells, indicating that this domain may have a more general role in\nmediating protein-protein interactions [[cite:PUB00043704]].\n\nThe profile we developed covers the entire DBB domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00043704":{"PMID":12767830,"ISBN":null,"volume":"329","issue":"3","year":2003,"title":"Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP.","URL":null,"raw_pages":"479-93","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Battersby A","Csiszar A","Leptin M","Wilson R."],"DOI_URL":"http://dx.doi.org/10.1016/S0022-2836(03)00489-3"},"PUB00043705":{"PMID":14993266,"ISBN":null,"volume":"24","issue":"6","year":2004,"title":"A functional domain of Dof that is required for fibroblast growth factor signaling.","URL":null,"raw_pages":"2263-76","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Wilson R","Battersby A","Csiszar A","Vogelsang E","Leptin M."],"DOI_URL":"http://dx.doi.org/10.1128/MCB.24.6.2263-2276.2004"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":2599,"pathways":0,"proteins":2598,"proteomes":1011,"sets":0,"structural_models":{"alphafold":2230,"bfvd":0},"structures":1,"taxa":3548},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}