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{
    "metadata": {
        "accession": "PF25087",
        "entry_id": null,
        "type": "repeat",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR056729",
        "hierarchy": null,
        "name": {
            "name": "GMPPB C-terminal domain",
            "short": "GMPPB_C"
        },
        "description": [
            {
                "text": "<p>This entry represents the C-terminal domain of GMPPB (Mannose-1-phosphate guanylyltransferase catalytic subunit beta), which consists of a left-handed parallel beta-helix composed of tandem repeats of a [LIV]-G-X(4) hexapeptide [[cite:PUB00155048]]. This protein catalyses the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids [[cite:PUB00155048]]. In S. pombe, it is required for proper septum structure and is involved cell cycle progression through cell-size checkpoint [[cite:PUB00098329]]. In budding yeasts Mgp1 (also known as Psa1) plays an important part in maintenance of cell-wall integrity [[cite:PUB00098328]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00098328": {
                "PMID": 11055399,
                "ISBN": null,
                "volume": "64",
                "issue": "9",
                "year": 2000,
                "title": "Defect in cell wall integrity of the yeast saccharomyces cerevisiae caused by a mutation of the GDP-mannose pyrophosphorylase gene VIG9.",
                "URL": null,
                "raw_pages": "1937-41",
                "medline_journal": "Biosci Biotechnol Biochem",
                "ISO_journal": "Biosci Biotechnol Biochem",
                "authors": [
                    "Yoda K",
                    "Kawada T",
                    "Kaibara C",
                    "Fujie A",
                    "Abe M",
                    "Hitoshi",
                    "Hashimoto",
                    "Shimizu J",
                    "Tomishige N",
                    "Noda Y",
                    "Yamasaki M."
                ],
                "DOI_URL": null
            },
            "PUB00155048": {
                "PMID": 33986552,
                "ISBN": null,
                "volume": "28",
                "issue": "5",
                "year": 2021,
                "title": "Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.",
                "URL": null,
                "raw_pages": "1-12",
                "medline_journal": "Nat Struct Mol Biol",
                "ISO_journal": "Nat Struct Mol Biol",
                "authors": [
                    "Zheng L",
                    "Liu Z",
                    "Wang Y",
                    "Yang F",
                    "Wang J",
                    "Huang W",
                    "Qin J",
                    "Tian M",
                    "Cai X",
                    "Liu X",
                    "Mo X",
                    "Gao N",
                    "Jia D."
                ],
                "DOI_URL": "https://doi.org/10.1038/s41594-021-00591-9"
            },
            "PUB00098329": {
                "PMID": 16049679,
                "ISBN": null,
                "volume": "274",
                "issue": "2",
                "year": 2005,
                "title": "Mpg1, a fission yeast protein required for proper septum structure, is involved in cell cycle progression through cell-size checkpoint.",
                "URL": null,
                "raw_pages": "155-67",
                "medline_journal": "Mol Genet Genomics",
                "ISO_journal": "Mol Genet Genomics",
                "authors": [
                    "Donoso I",
                    "Munoz-Centeno MC",
                    "Sanchez-Duran MA",
                    "Flores A",
                    "Daga RR",
                    "Guevara CM",
                    "Bejarano ER."
                ],
                "DOI_URL": null
            }
        },
        "set_info": {
            "accession": "CL0536",
            "name": "HEXAPEP"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 249,
            "interactions": 0,
            "matches": 29477,
            "pathways": 0,
            "proteins": 29432,
            "proteomes": 12234,
            "sets": 1,
            "structural_models": {
                "alphafold": 24131,
                "bfvd": 2
            },
            "structures": 50,
            "taxa": 25075
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 83,
            "alignment:full": 12997
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}