{"metadata":{"accession":"PF25087","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR056729","hierarchy":null,"name":{"name":"GMPPB C-terminal domain","short":"GMPPB_C"},"description":[{"text":"<p>This entry represents the C-terminal domain of GMPPB (Mannose-1-phosphate guanylyltransferase catalytic subunit beta), which consists of a left-handed parallel beta-helix composed of tandem repeats of a [LIV]-G-X(4) hexapeptide [[cite:PUB00155048]]. This protein catalyses the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids [[cite:PUB00155048]]. In S. pombe, it is required for proper septum structure and is involved cell cycle progression through cell-size checkpoint [[cite:PUB00098329]]. In budding yeasts Mgp1 (also known as Psa1) plays an important part in maintenance of cell-wall integrity [[cite:PUB00098328]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098328":{"PMID":11055399,"ISBN":null,"volume":"64","issue":"9","year":2000,"title":"Defect in cell wall integrity of the yeast saccharomyces cerevisiae caused by a mutation of the GDP-mannose pyrophosphorylase gene VIG9.","URL":null,"raw_pages":"1937-41","medline_journal":"Biosci Biotechnol Biochem","ISO_journal":"Biosci Biotechnol Biochem","authors":["Yoda K","Kawada T","Kaibara C","Fujie A","Abe M","Hitoshi","Hashimoto","Shimizu J","Tomishige N","Noda Y","Yamasaki M."],"DOI_URL":null},"PUB00155048":{"PMID":33986552,"ISBN":null,"volume":"28","issue":"5","year":2021,"title":"Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.","URL":null,"raw_pages":"1-12","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Zheng L","Liu Z","Wang Y","Yang F","Wang J","Huang W","Qin J","Tian M","Cai X","Liu X","Mo X","Gao N","Jia D."],"DOI_URL":"https://doi.org/10.1038/s41594-021-00591-9"},"PUB00098329":{"PMID":16049679,"ISBN":null,"volume":"274","issue":"2","year":2005,"title":"Mpg1, a fission yeast protein required for proper septum structure, is involved in cell cycle progression through cell-size checkpoint.","URL":null,"raw_pages":"155-67","medline_journal":"Mol Genet Genomics","ISO_journal":"Mol Genet Genomics","authors":["Donoso I","Munoz-Centeno MC","Sanchez-Duran MA","Flores A","Daga RR","Guevara CM","Bejarano ER."],"DOI_URL":null}},"set_info":{"accession":"CL0536","name":"HEXAPEP"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":249,"interactions":0,"matches":29477,"pathways":0,"proteins":29432,"proteomes":12234,"sets":1,"structural_models":{"alphafold":24131,"bfvd":2},"structures":50,"taxa":25075},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":83,"alignment:full":12997},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}