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{
"metadata": {
"accession": "PF23377",
"entry_id": null,
"type": "repeat",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR056152",
"hierarchy": null,
"name": {
"name": "IFT122 second beta-propeller",
"short": "Beta-prop_IFT122_2nd"
},
"description": [
{
"text": "<p>IFT122 is one of the core components (together with WDR19/IFT144 and IFT140) of the IFT-A complex which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), being involved in cilia function and/or assembly [[cite:PUB00155528],[cite:PUB00101516]]. IFT-A polymerises interacts with IFT-B, and uses an array of beta-propeller and TPR domains to create 'carriages' of the IFT train that engage TULP adaptor proteins [[cite:PUB00101516]]. This entry represents the second beta-propeller of IFT122, which is a crucial subunit for IFT-A integrity [[cite:PUB00155528]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00155529": {
"PMID": 27932497,
"ISBN": null,
"volume": "28",
"issue": "3",
"year": 2017,
"title": "Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors.",
"URL": null,
"raw_pages": "429-439",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol Biol Cell",
"authors": [
"Hirano T",
"Katoh Y",
"Nakayama K."
],
"DOI_URL": "https://doi.org/10.1091/mbc.E16-11-0813"
},
"PUB00155528": {
"PMID": 36462505,
"ISBN": null,
"volume": "185",
"issue": "26",
"year": 2022,
"title": "IFT-A structure reveals carriages for membrane protein transport into cilia.",
"URL": null,
"raw_pages": "4971-4985.e16",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Hesketh SJ",
"Mukhopadhyay AG",
"Nakamura D",
"Toropova K",
"Roberts AJ."
],
"DOI_URL": "https://doi.org/10.1016/j.cell.2022.11.010"
},
"PUB00101516": {
"PMID": 29220510,
"ISBN": null,
"volume": "27",
"issue": "3",
"year": 2018,
"title": "Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.",
"URL": null,
"raw_pages": "516-528",
"medline_journal": "Hum Mol Genet",
"ISO_journal": "Hum Mol Genet",
"authors": [
"Takahara M",
"Katoh Y",
"Nakamura K",
"Hirano T",
"Sugawa M",
"Tsurumi Y",
"Nakayama K."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "CL0186",
"name": "Beta_propeller"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 115,
"interactions": 0,
"matches": 2815,
"pathways": 0,
"proteins": 2732,
"proteomes": 1222,
"sets": 1,
"structural_models": {
"alphafold": 2299,
"bfvd": 0
},
"structures": 13,
"taxa": 4350
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 75,
"alignment:full": 1901
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
