{"metadata":{"accession":"PF23377","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR056152","hierarchy":null,"name":{"name":"IFT122 second beta-propeller","short":"Beta-prop_IFT122_2nd"},"description":[{"text":"<p>IFT122 is one of the core components (together with WDR19/IFT144 and IFT140) of the IFT-A complex which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), being involved in cilia function and/or assembly [[cite:PUB00155528],[cite:PUB00101516]]. IFT-A polymerises interacts with IFT-B, and uses an array of beta-propeller and TPR domains to create 'carriages' of the IFT train that engage TULP adaptor proteins [[cite:PUB00101516]]. This entry represents the second beta-propeller of IFT122, which is a crucial subunit for IFT-A integrity [[cite:PUB00155528]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155529":{"PMID":27932497,"ISBN":null,"volume":"28","issue":"3","year":2017,"title":"Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors.","URL":null,"raw_pages":"429-439","medline_journal":"Mol Biol Cell","ISO_journal":"Mol Biol Cell","authors":["Hirano T","Katoh Y","Nakayama K."],"DOI_URL":"https://doi.org/10.1091/mbc.E16-11-0813"},"PUB00155528":{"PMID":36462505,"ISBN":null,"volume":"185","issue":"26","year":2022,"title":"IFT-A structure reveals carriages for membrane protein transport into cilia.","URL":null,"raw_pages":"4971-4985.e16","medline_journal":"Cell","ISO_journal":"Cell","authors":["Hesketh SJ","Mukhopadhyay AG","Nakamura D","Toropova K","Roberts AJ."],"DOI_URL":"https://doi.org/10.1016/j.cell.2022.11.010"},"PUB00101516":{"PMID":29220510,"ISBN":null,"volume":"27","issue":"3","year":2018,"title":"Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.","URL":null,"raw_pages":"516-528","medline_journal":"Hum Mol Genet","ISO_journal":"Hum Mol Genet","authors":["Takahara M","Katoh Y","Nakamura K","Hirano T","Sugawa M","Tsurumi Y","Nakayama K."],"DOI_URL":null}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":115,"interactions":0,"matches":2815,"pathways":0,"proteins":2732,"proteomes":1222,"sets":1,"structural_models":{"alphafold":2299,"bfvd":0},"structures":13,"taxa":4350},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":75,"alignment:full":1901},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}