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{
"metadata": {
"accession": "PF22195",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR054019",
"hierarchy": null,
"name": {
"name": "CFP-like, C-terminal thrombospondin type 1 domain",
"short": "TSP1_CFP_C"
},
"description": [
{
"text": "<p>This domain is found at the C-terminal end of human Properdin (CFP, for Complement factor P) and similar animal proteins. CFP is a positive regulator of the alternate pathway (AP) of complement. It contains six thrombospondin repeat type I (TSP 1-6 domains and an N-terminal domain ([pfam:PF18487]). This entry represents the last TSP type I domain, which binds to the first TSP type I domain ([pfam:PF00090]), contributing to multimerisation [[cite:PUB00027123],[cite:PUB00038006],[cite:PUB00153864],[cite:PUB00153865],[cite:PUB00153866]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00153866": {
"PMID": 31552043,
"ISBN": null,
"volume": "10",
"issue": null,
"year": 2019,
"title": "Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.",
"URL": null,
"raw_pages": "2097",
"medline_journal": "Front Immunol",
"ISO_journal": "Front Immunol",
"authors": [
"van den Bos RM",
"Pearce NM",
"Granneman J",
"Brondijk THC",
"Gros P."
],
"DOI_URL": "https://doi.org/10.3389/fimmu.2019.02097"
},
"PUB00153864": {
"PMID": 21821127,
"ISBN": null,
"volume": "80",
"issue": "2",
"year": 2011,
"title": "Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system.",
"URL": null,
"raw_pages": "253-9",
"medline_journal": "Protein Expr Purif",
"ISO_journal": "Protein Expr Purif",
"authors": [
"Klenotic PA",
"Page RC",
"Misra S",
"Silverstein RL."
],
"DOI_URL": "https://doi.org/10.1016/j.pep.2011.07.010"
},
"PUB00038006": {
"PMID": 15491616,
"ISBN": null,
"volume": "343",
"issue": "5",
"year": 2004,
"title": "The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling.",
"URL": null,
"raw_pages": "1327-43",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Sun Z",
"Reid KB",
"Perkins SJ."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2004.09.001"
},
"PUB00027123": {
"PMID": 12391027,
"ISBN": null,
"volume": "159",
"issue": "2",
"year": 2002,
"title": "Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication.",
"URL": null,
"raw_pages": "373-82",
"medline_journal": "J Cell Biol",
"ISO_journal": "J. Cell Biol.",
"authors": [
"Tan K",
"Duquette M",
"Liu JH",
"Dong Y",
"Zhang R",
"Joachimiak A",
"Lawler J",
"Wang JH."
],
"DOI_URL": "http://dx.doi.org/10.1083/jcb.200206062"
},
"PUB00153868": {
"PMID": 36173177,
"ISBN": null,
"volume": "31",
"issue": "10",
"year": 2022,
"title": "Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging.",
"URL": null,
"raw_pages": "e4432",
"medline_journal": "Protein Sci",
"ISO_journal": "Protein Sci",
"authors": [
"Lorentzen J",
"Pedersen DV",
"Gadeberg TAF",
"Andersen GR."
],
"DOI_URL": "https://doi.org/10.1002/pro.4432"
},
"PUB00153865": {
"PMID": 31507604,
"ISBN": null,
"volume": "10",
"issue": null,
"year": 2019,
"title": "Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.",
"URL": null,
"raw_pages": "2007",
"medline_journal": "Front Immunol",
"ISO_journal": "Front Immunol",
"authors": [
"Pedersen DV",
"Gadeberg TAF",
"Thomas C",
"Wang Y",
"Joram N",
"Jensen RK",
"Mazarakis SMM",
"Revel M",
"El Sissy C",
"Petersen SV",
"Lindorff-Larsen K",
"Thiel S",
"Laursen NS",
"Fremeaux-Bacchi V",
"Andersen GR."
],
"DOI_URL": "https://doi.org/10.3389/fimmu.2019.02007"
},
"PUB00153867": {
"PMID": 35031611,
"ISBN": null,
"volume": "13",
"issue": "1",
"year": 2022,
"title": "Structure and function of a family of tick-derived complement inhibitors targeting properdin.",
"URL": null,
"raw_pages": "317",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Braunger K",
"Ahn J",
"Jore MM",
"Johnson S",
"Tang TTL",
"Pedersen DV",
"Andersen GR",
"Lea SM."
],
"DOI_URL": "https://doi.org/10.1038/s41467-021-27920-2"
}
},
"set_info": {
"accession": "CL0692",
"name": "TSP1"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 33,
"interactions": 0,
"matches": 585,
"pathways": 0,
"proteins": 583,
"proteomes": 356,
"sets": 1,
"structural_models": {
"alphafold": 546,
"bfvd": 0
},
"structures": 13,
"taxa": 1332
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 7,
"alignment:full": 417
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
