"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"PF22195"	"{'subfamilies': 0, 'domain_architectures': 30, 'interactions': 0, 'matches': 541, 'pathways': 0, 'proteins': 540, 'proteomes': 371, 'sets': 1, 'structural_models': {'alphafold': 478}, 'structures': 14, 'taxa': 1345}"	"{}"	"[{'text': '<p>This domain is found at the C-terminal end of human Properdin (CFP, for Complement factor P) and similar animal proteins. CFP is a positive regulator of the alternate pathway (AP) of complement. It contains six thrombospondin repeat type I (TSP 1-6 domains and an N-terminal domain ([pfam:PF18487]). This entry represents the last TSP type I domain, which binds to the first TSP type I domain ([pfam:PF00090]), contributing to multimerisation [[cite:PUB00027123],[cite:PUB00038006],[cite:PUB00153864],[cite:PUB00153865],[cite:PUB00153866]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR054019"	False	False	False	"{'PUB00153866': {'PMID': 31552043, 'ISBN': None, 'volume': '10', 'issue': None, 'year': 2019, 'title': 'Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.', 'URL': None, 'raw_pages': '2097', 'medline_journal': 'Front Immunol', 'ISO_journal': 'Front Immunol', 'authors': ['van den Bos RM', 'Pearce NM', 'Granneman J', 'Brondijk THC', 'Gros P.'], 'DOI_URL': 'https://doi.org/10.3389/fimmu.2019.02097'}, 'PUB00027123': {'PMID': 12391027, 'ISBN': None, 'volume': '159', 'issue': '2', 'year': 2002, 'title': 'Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication.', 'URL': None, 'raw_pages': '373-82', 'medline_journal': 'J Cell Biol', 'ISO_journal': 'J. Cell Biol.', 'authors': ['Tan K', 'Duquette M', 'Liu JH', 'Dong Y', 'Zhang R', 'Joachimiak A', 'Lawler J', 'Wang JH.'], 'DOI_URL': 'http://dx.doi.org/10.1083/jcb.200206062'}, 'PUB00153864': {'PMID': 21821127, 'ISBN': None, 'volume': '80', 'issue': '2', 'year': 2011, 'title': 'Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system.', 'URL': None, 'raw_pages': '253-9', 'medline_journal': 'Protein Expr Purif', 'ISO_journal': 'Protein Expr Purif', 'authors': ['Klenotic PA', 'Page RC', 'Misra S', 'Silverstein RL.'], 'DOI_URL': 'https://doi.org/10.1016/j.pep.2011.07.010'}, 'PUB00038006': {'PMID': 15491616, 'ISBN': None, 'volume': '343', 'issue': '5', 'year': 2004, 'title': 'The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling.', 'URL': None, 'raw_pages': '1327-43', 'medline_journal': 'J Mol Biol', 'ISO_journal': 'J. Mol. Biol.', 'authors': ['Sun Z', 'Reid KB', 'Perkins SJ.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.jmb.2004.09.001'}, 'PUB00153867': {'PMID': 35031611, 'ISBN': None, 'volume': '13', 'issue': '1', 'year': 2022, 'title': 'Structure and function of a family of tick-derived complement inhibitors targeting properdin.', 'URL': None, 'raw_pages': '317', 'medline_journal': 'Nat Commun', 'ISO_journal': 'Nat Commun', 'authors': ['Braunger K', 'Ahn J', 'Jore MM', 'Johnson S', 'Tang TTL', 'Pedersen DV', 'Andersen GR', 'Lea SM.'], 'DOI_URL': 'https://doi.org/10.1038/s41467-021-27920-2'}, 'PUB00153868': {'PMID': 36173177, 'ISBN': None, 'volume': '31', 'issue': '10', 'year': 2022, 'title': 'Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging.', 'URL': None, 'raw_pages': 'e4432', 'medline_journal': 'Protein Sci', 'ISO_journal': 'Protein Sci', 'authors': ['Lorentzen J', 'Pedersen DV', 'Gadeberg TAF', 'Andersen GR.'], 'DOI_URL': 'https://doi.org/10.1002/pro.4432'}, 'PUB00153865': {'PMID': 31507604, 'ISBN': None, 'volume': '10', 'issue': None, 'year': 2019, 'title': 'Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.', 'URL': None, 'raw_pages': '2007', 'medline_journal': 'Front Immunol', 'ISO_journal': 'Front Immunol', 'authors': ['Pedersen DV', 'Gadeberg TAF', 'Thomas C', 'Wang Y', 'Joram N', 'Jensen RK', 'Mazarakis SMM', 'Revel M', 'El Sissy C', 'Petersen SV', 'Lindorff-Larsen K', 'Thiel S', 'Laursen NS', 'Fremeaux-Bacchi V', 'Andersen GR.'], 'DOI_URL': 'https://doi.org/10.3389/fimmu.2019.02007'}}"	""	"{'name': 'CFP-like, C-terminal thrombospondin type 1 domain', 'short': 'TSP1_CFP_C'}"	""	""	"{'accession': 'CL0692', 'name': 'TSP1'}"	"pfam"	"domain"	""