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{
"metadata": {
"accession": "PF21362",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR049548",
"hierarchy": null,
"name": {
"name": "E3 ubiquitin-protein ligase sina/sinah, RING finger",
"short": "Sina_RING"
},
"description": [
{
"text": "<p>This is the RING finger domain of Sina and its homologues from animals, Sinah1/2 and plants, such as SINAT3 from Arabidopsis [[cite:PUB00101320]]. Sina (seven in absentia) was first identified in Drosophila and is essential for the determination of the R7 pathway in photoreceptor cell development. It consists of a RING zinc finger at the N-terminal, followed by two zinc finger (C2H2 type) domains ([pfam:PF21361]) and a C-terminal TRAF-like domain ([pfam:PF03145]) [[cite:PUB00101319],[cite:PUB00047035]]. This domain gives the E3 ubiquitin ligase activity to these proteins.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00047035": {
"PMID": 16615911,
"ISBN": null,
"volume": "14",
"issue": "4",
"year": 2006,
"title": "Elucidation of the substrate binding site of Siah ubiquitin ligase.",
"URL": null,
"raw_pages": "695-701",
"medline_journal": "Structure",
"ISO_journal": "Structure",
"authors": [
"House CM",
"Hancock NC",
"Moller A",
"Cromer BA",
"Fedorov V",
"Bowtell DD",
"Parker MW",
"Polekhina G."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.str.2005.12.013"
},
"PUB00101320": {
"PMID": 32753431,
"ISBN": null,
"volume": "32",
"issue": "10",
"year": 2020,
"title": "SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling.",
"URL": null,
"raw_pages": "3290-3310",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Xia FN",
"Zeng B",
"Liu HS",
"Qi H",
"Xie LJ",
"Yu LJ",
"Chen QF",
"Li JF",
"Chen YQ",
"Jiang L",
"Xiao S."
],
"DOI_URL": null
},
"PUB00101319": {
"PMID": 24316825,
"ISBN": null,
"volume": "69",
"issue": "Pt 12",
"year": 2013,
"title": "Two high-resolution structures of the human E3 ubiquitin ligase Siah1.",
"URL": null,
"raw_pages": "1339-43",
"medline_journal": "Acta Crystallogr Sect F Struct Biol Cryst Commun",
"ISO_journal": "Acta Crystallogr Sect F Struct Biol Cryst Commun",
"authors": [
"Rimsa V",
"Eadsforth TC",
"Hunter WN."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "CL0229",
"name": "RING"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 205,
"interactions": 0,
"matches": 12235,
"pathways": 0,
"proteins": 12117,
"proteomes": 1632,
"sets": 1,
"structural_models": {
"alphafold": 10669,
"bfvd": 4
},
"structures": 1,
"taxa": 7503
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 226,
"alignment:full": 6432
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
