"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"PF21362"	"{'subfamilies': 0, 'domain_architectures': 205, 'interactions': 0, 'matches': 12235, 'pathways': 0, 'proteins': 12117, 'proteomes': 1632, 'sets': 1, 'structural_models': {'alphafold': 10669, 'bfvd': 4}, 'structures': 1, 'taxa': 7503}"	"{}"	"[{'text': '<p>This is the RING finger domain of Sina and its homologues from animals, Sinah1/2 and plants, such as SINAT3 from Arabidopsis [[cite:PUB00101320]]. Sina (seven in absentia) was first identified in Drosophila and is essential for the determination of the R7 pathway in photoreceptor cell development. It consists of a RING zinc finger at the N-terminal, followed by two zinc  finger (C2H2 type) domains ([pfam:PF21361]) and a C-terminal TRAF-like domain ([pfam:PF03145]) [[cite:PUB00101319],[cite:PUB00047035]]. This domain gives the E3 ubiquitin ligase activity to these proteins.</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR049548"	False	False	False	"{'PUB00047035': {'PMID': 16615911, 'ISBN': None, 'volume': '14', 'issue': '4', 'year': 2006, 'title': 'Elucidation of the substrate binding site of Siah ubiquitin ligase.', 'URL': None, 'raw_pages': '695-701', 'medline_journal': 'Structure', 'ISO_journal': 'Structure', 'authors': ['House CM', 'Hancock NC', 'Moller A', 'Cromer BA', 'Fedorov V', 'Bowtell DD', 'Parker MW', 'Polekhina G.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.str.2005.12.013'}, 'PUB00101320': {'PMID': 32753431, 'ISBN': None, 'volume': '32', 'issue': '10', 'year': 2020, 'title': 'SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling.', 'URL': None, 'raw_pages': '3290-3310', 'medline_journal': 'Plant Cell', 'ISO_journal': 'Plant Cell', 'authors': ['Xia FN', 'Zeng B', 'Liu HS', 'Qi H', 'Xie LJ', 'Yu LJ', 'Chen QF', 'Li JF', 'Chen YQ', 'Jiang L', 'Xiao S.'], 'DOI_URL': None}, 'PUB00101319': {'PMID': 24316825, 'ISBN': None, 'volume': '69', 'issue': 'Pt 12', 'year': 2013, 'title': 'Two high-resolution structures of the human E3 ubiquitin ligase Siah1.', 'URL': None, 'raw_pages': '1339-43', 'medline_journal': 'Acta Crystallogr Sect F Struct Biol Cryst Commun', 'ISO_journal': 'Acta Crystallogr Sect F Struct Biol Cryst Commun', 'authors': ['Rimsa V', 'Eadsforth TC', 'Hunter WN.'], 'DOI_URL': None}}"	""	"{'name': 'E3 ubiquitin-protein ligase sina/sinah, RING finger', 'short': 'Sina_RING'}"	""	""	"{'accession': 'CL0229', 'name': 'RING'}"	"pfam"	"domain"	""