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{
    "metadata": {
        "accession": "PF21130",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR048451",
        "hierarchy": null,
        "name": {
            "name": "YgfZ, beta-barrel domain",
            "short": "YgfZ_barrel"
        },
        "description": [
            {
                "text": "<p>YgfZ is a folate-binding protein involved in regulating the level of ATP-dnaA and in the modification of some tRNAs [[cite:PUB00022265],[cite:PUB00043084]]. It consists of a folate-binding domain at the N-terminal ([pfam:PF01571]) and a six-stranded antiparallel beta-barrel at the C-terminal, represented in this entry, with identical topology found at the C-terminal of elongation factors Tu and eEF-1alpha and in the gamma subunit of the initiation factor eIF2 [[cite:PUB00022265]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00022265": {
                "PMID": 15489424,
                "ISBN": null,
                "volume": "186",
                "issue": "21",
                "year": 2004,
                "title": "Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism.",
                "URL": null,
                "raw_pages": "7134-40",
                "medline_journal": "J Bacteriol",
                "ISO_journal": "J. Bacteriol.",
                "authors": [
                    "Teplyakov A",
                    "Obmolova G",
                    "Sarikaya E",
                    "Pullalarevu S",
                    "Krajewski W",
                    "Galkin A",
                    "Howard AJ",
                    "Herzberg O",
                    "Gilliland GL."
                ],
                "DOI_URL": "http://dx.doi.org/10.1128/JB.186.21.7134-7140.2004"
            },
            "PUB00043084": {
                "PMID": 16359333,
                "ISBN": null,
                "volume": "59",
                "issue": "1",
                "year": 2006,
                "title": "Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation.",
                "URL": null,
                "raw_pages": "265-75",
                "medline_journal": "Mol Microbiol",
                "ISO_journal": "Mol. Microbiol.",
                "authors": [
                    "Ote T",
                    "Hashimoto M",
                    "Ikeuchi Y",
                    "Su'etsugu M",
                    "Suzuki T",
                    "Katayama T",
                    "Kato J."
                ],
                "DOI_URL": "http://dx.doi.org/10.1111/j.1365-2958.2005.04932.x"
            }
        },
        "set_info": {
            "accession": "CL0740",
            "name": "GCV_T_C"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 2,
            "interactions": 0,
            "matches": 2692,
            "pathways": 0,
            "proteins": 2692,
            "proteomes": 1235,
            "sets": 1,
            "structural_models": {
                "alphafold": 2205,
                "bfvd": 0
            },
            "structures": 2,
            "taxa": 2302
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 34,
            "alignment:full": 428
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}