{"metadata":{"accession":"PF21130","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048451","hierarchy":null,"name":{"name":"YgfZ, beta-barrel domain","short":"YgfZ_barrel"},"description":[{"text":"<p>YgfZ is a folate-binding protein involved in regulating the level of ATP-dnaA and in the modification of some tRNAs [[cite:PUB00022265],[cite:PUB00043084]]. It consists of a folate-binding domain at the N-terminal ([pfam:PF01571]) and a six-stranded antiparallel beta-barrel at the C-terminal, represented in this entry, with identical topology found at the C-terminal of elongation factors Tu and eEF-1alpha and in the gamma subunit of the initiation factor eIF2 [[cite:PUB00022265]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00022265":{"PMID":15489424,"ISBN":null,"volume":"186","issue":"21","year":2004,"title":"Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism.","URL":null,"raw_pages":"7134-40","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Teplyakov A","Obmolova G","Sarikaya E","Pullalarevu S","Krajewski W","Galkin A","Howard AJ","Herzberg O","Gilliland GL."],"DOI_URL":"http://dx.doi.org/10.1128/JB.186.21.7134-7140.2004"},"PUB00043084":{"PMID":16359333,"ISBN":null,"volume":"59","issue":"1","year":2006,"title":"Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation.","URL":null,"raw_pages":"265-75","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Ote T","Hashimoto M","Ikeuchi Y","Su'etsugu M","Suzuki T","Katayama T","Kato J."],"DOI_URL":"http://dx.doi.org/10.1111/j.1365-2958.2005.04932.x"}},"set_info":{"accession":"CL0740","name":"GCV_T_C"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":2692,"pathways":0,"proteins":2692,"proteomes":1235,"sets":1,"structural_models":{"alphafold":2205,"bfvd":0},"structures":2,"taxa":2302},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":34,"alignment:full":428},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}