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{
    "metadata": {
        "accession": "PF09807",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR018627",
        "hierarchy": null,
        "name": {
            "name": "Elongation complex protein 6",
            "short": "ELP6"
        },
        "description": [
            {
                "text": "<p>ELP6 is a subunit of the RNA polymerase II elongator complex. The Elongator complex promotes RNA-polymerase II transcript elongation through histone acetylation in the nucleus and tRNA modification in the cytoplasm. ELP5 and ELP6 play a major role in the migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator [[cite:PUB00075653]]</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00075653": {
                "PMID": 22854966,
                "ISBN": null,
                "volume": "287",
                "issue": "39",
                "year": 2012,
                "title": "DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.",
                "URL": null,
                "raw_pages": "32535-45",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Close P",
                    "Gillard M",
                    "Ladang A",
                    "Jiang Z",
                    "Papuga J",
                    "Hawkes N",
                    "Nguyen L",
                    "Chapelle JP",
                    "Bouillenne F",
                    "Svejstrup J",
                    "Fillet M",
                    "Chariot A."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.M112.402727"
            }
        },
        "set_info": {
            "accession": "CL0023",
            "name": "P-loop_NTPase"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 51,
            "interactions": 0,
            "matches": 2963,
            "pathways": 0,
            "proteins": 2802,
            "proteomes": 2010,
            "sets": 1,
            "structural_models": {
                "alphafold": 2509,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 6235
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 15,
            "alignment:full": 2047
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}