{"metadata":{"accession":"PF09807","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018627","hierarchy":null,"name":{"name":"Elongation complex protein 6","short":"ELP6"},"description":[{"text":"<p>ELP6 is a subunit of the RNA polymerase II elongator complex. The Elongator complex promotes RNA-polymerase II transcript elongation through histone acetylation in the nucleus and tRNA modification in the cytoplasm. ELP5 and ELP6 play a major role in the migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator [[cite:PUB00075653]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075653":{"PMID":22854966,"ISBN":null,"volume":"287","issue":"39","year":2012,"title":"DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.","URL":null,"raw_pages":"32535-45","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Close P","Gillard M","Ladang A","Jiang Z","Papuga J","Hawkes N","Nguyen L","Chapelle JP","Bouillenne F","Svejstrup J","Fillet M","Chariot A."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M112.402727"}},"set_info":{"accession":"CL0023","name":"P-loop_NTPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":51,"interactions":0,"matches":2963,"pathways":0,"proteins":2802,"proteomes":2010,"sets":1,"structural_models":{"alphafold":2509,"bfvd":0},"structures":0,"taxa":6235},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":2047},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}