HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "PF08397",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR013606",
"hierarchy": null,
"name": {
"name": "IRSp53/MIM homology domain",
"short": "IMD"
},
"description": [
{
"text": "<p>The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent [[cite:PUB00020898]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": [
{
"title": "IMD_domain",
"extract": "<p>In molecular biology, the <b>IMD domain</b> is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate p53 (IRSp53/BAIAP2) and in the evolutionarily related IRSp53/MIM (MTSS1) family. In IRSp53, a ubiquitous regulator of the actin cytoskeleton, the IMD domain acts as conserved F-actin bundling domain involved in filopodium formation. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent. The IRSp53/MIM family is a novel F-actin bundling protein family that includes invertebrate relatives:</p><ul><li>Vertebrate MIM (MTSS1), an actin-binding scaffold protein that may be involved in cancer metastasis.</li>\n<li>Vertebrate ABBA-1 (MTSS1L), a MIM-related protein.</li>\n<li>Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2 or insulin receptor tyrosine kinase substrate p53 (IRSp53), a multifunctional adaptor protein that links Rac1 with a Wiskott–Aldrich syndrome family verprolin-homologous protein 2 (WAVE2/WASF2) to induce lamellipodia or Cdc42 with Mena to induce filopodia.</li>\n<li>Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2-like proteins 1 and 2.</li>\n<li><i>Drosophila melanogaster</i> CG32082-PA.</li>\n<li><i>Caenorhabditis elegans</i> M04F3.5 protein.</li></ul>",
"thumbnail": null
}
],
"literature": {
"PUB00020898": {
"PMID": 14752106,
"ISBN": null,
"volume": "279",
"issue": "15",
"year": 2004,
"title": "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.",
"URL": null,
"raw_pages": "14929-36",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Yamagishi A",
"Masuda M",
"Ohki T",
"Onishi H",
"Mochizuki N."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M309408200"
}
},
"set_info": {
"accession": "CL0145",
"name": "Golgi-transport"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 96,
"interactions": 0,
"matches": 13143,
"pathways": 0,
"proteins": 12516,
"proteomes": 1320,
"sets": 1,
"structural_models": {
"alphafold": 11009,
"bfvd": 0
},
"structures": 6,
"taxa": 4466
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 4,
"alignment:full": 9100
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "2d1l",
"name": "Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)"
}
}
}
