{"metadata":{"accession":"PF08397","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013606","hierarchy":null,"name":{"name":"IRSp53/MIM homology domain","short":"IMD"},"description":[{"text":"<p>The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent [[cite:PUB00020898]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"IMD_domain","extract":"<p>In molecular biology, the <b>IMD domain</b> is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate p53 (IRSp53/BAIAP2) and in the evolutionarily related IRSp53/MIM (MTSS1) family. In IRSp53, a ubiquitous regulator of the actin cytoskeleton, the IMD domain acts as conserved F-actin bundling domain involved in filopodium formation. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent. The IRSp53/MIM family is a novel F-actin bundling protein family that includes invertebrate relatives:</p><ul><li>Vertebrate MIM (MTSS1), an actin-binding scaffold protein that may be involved in cancer metastasis.</li>\n<li>Vertebrate ABBA-1 (MTSS1L), a MIM-related protein.</li>\n<li>Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2 or insulin receptor tyrosine kinase substrate p53 (IRSp53), a multifunctional adaptor protein that links Rac1 with a Wiskott–Aldrich syndrome family verprolin-homologous protein 2 (WAVE2/WASF2) to induce lamellipodia or Cdc42 with Mena to induce filopodia.</li>\n<li>Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2-like proteins 1 and 2.</li>\n<li><i>Drosophila melanogaster</i> CG32082-PA.</li>\n<li><i>Caenorhabditis elegans</i> M04F3.5 protein.</li></ul>","thumbnail":null}],"literature":{"PUB00020898":{"PMID":14752106,"ISBN":null,"volume":"279","issue":"15","year":2004,"title":"A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.","URL":null,"raw_pages":"14929-36","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Yamagishi A","Masuda M","Ohki T","Onishi H","Mochizuki N."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M309408200"}},"set_info":{"accession":"CL0145","name":"Golgi-transport"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":96,"interactions":0,"matches":13143,"pathways":0,"proteins":12516,"proteomes":1320,"sets":1,"structural_models":{"alphafold":11009,"bfvd":0},"structures":6,"taxa":4466},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":9100},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2d1l","name":"Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)"}}}