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{
"metadata": {
"accession": "PF07837",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "pfam",
"member_databases": null,
"integrated": "IPR012886",
"hierarchy": null,
"name": {
"name": "Formiminotransferase domain, N-terminal subdomain",
"short": "FTCD_N"
},
"description": [
{
"text": "<p>The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains [[cite:PUB00007432]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": [
{
"title": "Glutamate_formimidoyltransferase",
"extract": "<p><b>Glutamate formimidoyltransferase</b> is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism. It catalyses two reactions. In the first, N-formimidoyl-L-glutamate transfers its formimidoyl group to tetrahydrofolate.\n</p>\n",
"thumbnail": null
}
],
"literature": {
"PUB00007432": {
"PMID": 10673422,
"ISBN": null,
"volume": "8",
"issue": "1",
"year": 2000,
"title": "The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme.",
"URL": null,
"raw_pages": "35-46",
"medline_journal": "Structure",
"ISO_journal": "Structure",
"authors": [
"Kohls D",
"Sulea T",
"Purisima EO",
"MacKenzie RE",
"Vrielink A."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0969-2126(00)00078-2"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 48,
"interactions": 0,
"matches": 5248,
"pathways": 0,
"proteins": 5179,
"proteomes": 2204,
"sets": 0,
"structural_models": {
"alphafold": 4594,
"bfvd": 0
},
"structures": 3,
"taxa": 6672
},
"entry_annotations": {
"hmm": 0,
"logo": 0,
"alignment:seed": 114,
"alignment:full": 3022
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "1qd1",
"name": "THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE."
}
}
}
