{"metadata":{"accession":"PF07837","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR012886","hierarchy":null,"name":{"name":"Formiminotransferase domain, N-terminal subdomain","short":"FTCD_N"},"description":[{"text":"<p>The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This,  in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a  short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to  form a number of contacts with residues found in both the N-terminal and C-terminal subdomains [[cite:PUB00007432]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Glutamate_formimidoyltransferase","extract":"<p><b>Glutamate formimidoyltransferase</b> is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism. It catalyses two reactions. In the first, N-formimidoyl-L-glutamate transfers its formimidoyl group to tetrahydrofolate.\n</p>\n","thumbnail":null}],"literature":{"PUB00007432":{"PMID":10673422,"ISBN":null,"volume":"8","issue":"1","year":2000,"title":"The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme.","URL":null,"raw_pages":"35-46","medline_journal":"Structure","ISO_journal":"Structure","authors":["Kohls D","Sulea T","Purisima EO","MacKenzie RE","Vrielink A."],"DOI_URL":"http://dx.doi.org/10.1016/S0969-2126(00)00078-2"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":48,"interactions":0,"matches":5248,"pathways":0,"proteins":5179,"proteomes":2204,"sets":0,"structural_models":{"alphafold":4594,"bfvd":0},"structures":3,"taxa":6672},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":114,"alignment:full":3022},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1qd1","name":"THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE."}}}