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{
    "metadata": {
        "accession": "PF05276",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR007940",
        "hierarchy": null,
        "name": {
            "name": "SH3 domain-binding protein 5 (SH3BP5)",
            "short": "SH3BP5"
        },
        "description": [
            {
                "text": "<p>This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vitro, and has been found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk).  Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule [[cite:PUB00010453]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00010453": {
                "PMID": 12167088,
                "ISBN": null,
                "volume": "367",
                "issue": "Pt 3",
                "year": 2002,
                "title": "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria.",
                "URL": null,
                "raw_pages": "577-85",
                "medline_journal": "Biochem J",
                "ISO_journal": "Biochem. J.",
                "authors": [
                    "Wiltshire C",
                    "Matsushita M",
                    "Tsukada S",
                    "Gillespie DA",
                    "May GH."
                ],
                "DOI_URL": "http://dx.doi.org/10.1042/BJ20020553"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 58,
            "interactions": 0,
            "matches": 3849,
            "pathways": 0,
            "proteins": 3719,
            "proteomes": 1250,
            "sets": 0,
            "structural_models": {
                "alphafold": 3395,
                "bfvd": 0
            },
            "structures": 5,
            "taxa": 4284
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 18,
            "alignment:full": 2529
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}